TY - JOUR
T1 - Role of red blood cells in thrombosis
AU - Andrews, Dina A.
AU - Low, Philip S.
PY - 1999
Y1 - 1999
N2 - Most biomedical textbooks teach that coagulation and thrombosis are primarily a function of endothelial cells, platelets, and soluble coagulation factors. Red blood cells, in contrast, are generally regarded as innocent bystanders, passively entrappeal in a developing thrombus as they flow through the vasculature. This review summarizes evidence that demonstrates an active role for red cells in normal and pathologic hemostasis. We then evaluate the possible molecular mechanisms whereby a usually inert erythrocyte can actively contribute to the processes of clot formation.
AB - Most biomedical textbooks teach that coagulation and thrombosis are primarily a function of endothelial cells, platelets, and soluble coagulation factors. Red blood cells, in contrast, are generally regarded as innocent bystanders, passively entrappeal in a developing thrombus as they flow through the vasculature. This review summarizes evidence that demonstrates an active role for red cells in normal and pathologic hemostasis. We then evaluate the possible molecular mechanisms whereby a usually inert erythrocyte can actively contribute to the processes of clot formation.
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U2 - 10.1097/00062752-199903000-00004
DO - 10.1097/00062752-199903000-00004
M3 - Review article
C2 - 10088636
AN - SCOPUS:0032811978
VL - 6
SP - 76
EP - 82
JO - Current Opinion in Hematology
JF - Current Opinion in Hematology
SN - 1065-6251
IS - 2
ER -