Role of red blood cells in thrombosis

Dina A. Andrews, Philip S. Low

Research output: Contribution to journalReview articlepeer-review

314 Scopus citations

Abstract

Most biomedical textbooks teach that coagulation and thrombosis are primarily a function of endothelial cells, platelets, and soluble coagulation factors. Red blood cells, in contrast, are generally regarded as innocent bystanders, passively entrappeal in a developing thrombus as they flow through the vasculature. This review summarizes evidence that demonstrates an active role for red cells in normal and pathologic hemostasis. We then evaluate the possible molecular mechanisms whereby a usually inert erythrocyte can actively contribute to the processes of clot formation.

Original languageEnglish (US)
Pages (from-to)76-82
Number of pages7
JournalCurrent Opinion in Hematology
Volume6
Issue number2
DOIs
StatePublished - 1999

ASJC Scopus subject areas

  • Hematology

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