Role of potassium channels in the central neurogenic neuroprotection elicited by cerebellar stimulation in rat

Eugene V. Golanov, John D. Christensen, Donald J. Reis

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Electrical stimulation of the cerebellar fastigial nucleus (FN) in spontaneously hypertensive (SHR), Wistar-Kyoto (WKY) and Fisher rats reduced, by ~ 50%, the infarctions produced by occlusion of the middle cerebral artery. Blockade of ATP-dependent potassium (K-ATP) channels with glibenclimide (i.c.v.) abolished salvage only in the SHR rat. While blockade of K-ATP channels failed to abolish salvage in WKY and Fisher rats, participation of potassium channels in neurogenic neuroprotection cannot be excluded.

Original languageEnglish (US)
Pages (from-to)496-500
Number of pages5
JournalBrain Research
Volume842
Issue number2
DOIs
StatePublished - Sep 25 1999

Keywords

  • ATP-dependent potassium channel
  • Cerebellar fastigial nucleus
  • Focal ischemia
  • Glibenclamide
  • Pre-conditioning
  • Stimulation

ASJC Scopus subject areas

  • Neuroscience(all)

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