Abstract

Endothelium-derived nitric oxide is a potent endogenous vasodilator that is derived from the metabolism of L-arginine. This endothelial factor inhibits circulating blood elements from interacting with the vessel wall. Platelet adherence and aggregation as well as monocyte adherence and infiltration are opposed by this paracrine substance. By virtue of these characteristics, endothelium-derived nitric oxide inhibits atherogenesis in animal models and may even induce regression.

Original languageEnglish (US)
Pages (from-to)419-424
Number of pages6
JournalWestern Journal of Medicine
Volume164
Issue number5
StatePublished - May 1996

ASJC Scopus subject areas

  • Medicine(all)

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