Role of HSPs and telomerase in radiotherapy

Tej K. Pandita

doi:10.1080/02656730500271700

Role of HSPs and telomerase in radiotherapy

Tej K. Pandita

Academic Institute

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The inability of radiotherapy to control tumour growth is still a daunting clinical problem leading to failure of the overall treatment regimens. The fundamental question is; could tumour cells be specifically sensitized to ionizing radiation (IR) by heat or factors exclusively expressed in tumour cells? One such factor, expressed in most tumours and silent in somatic cells, is telomerase. Biochemical and genetic studies have established an association between telomere maintenance and extended life span of human cells mediated through the expression of the catalytic sub-unit of telomerase (hTERT). Because of this, telomerase is an attractive target for inhibition in anti-cancer therapy. Telomeres are maintained by telomerase and hTERT interacts with heat shock protein (HSP) chaperones. This review will focus on the possible role of HSPs and telomerase in sensitizing tumour cells and, thus, enhancing the potential of targeted radiotherapy.

Original language	English (US)
Pages (from-to)	689-694
Number of pages	6
Journal	International Journal of Hyperthermia
Volume	21
Issue number	8
DOIs	https://doi.org/10.1080/02656730500271700
State	Published - Dec 2005

Keywords

HSP70
HSP90
Telomerase
Telomeres

ASJC Scopus subject areas

Cancer Research
Radiological and Ultrasound Technology

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10.1080/02656730500271700

Cite this

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title = "Role of HSPs and telomerase in radiotherapy",

abstract = "The inability of radiotherapy to control tumour growth is still a daunting clinical problem leading to failure of the overall treatment regimens. The fundamental question is; could tumour cells be specifically sensitized to ionizing radiation (IR) by heat or factors exclusively expressed in tumour cells? One such factor, expressed in most tumours and silent in somatic cells, is telomerase. Biochemical and genetic studies have established an association between telomere maintenance and extended life span of human cells mediated through the expression of the catalytic sub-unit of telomerase (hTERT). Because of this, telomerase is an attractive target for inhibition in anti-cancer therapy. Telomeres are maintained by telomerase and hTERT interacts with heat shock protein (HSP) chaperones. This review will focus on the possible role of HSPs and telomerase in sensitizing tumour cells and, thus, enhancing the potential of targeted radiotherapy.",

keywords = "HSP70, HSP90, Telomerase, Telomeres",

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note = "Funding Information: The work is supported by NIH (NS34746, CA10445-Project 2), Department of Defense, and Funds from Radiation Oncology, Washington University School of Medicine.",

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AU - Pandita, Tej K.

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N2 - The inability of radiotherapy to control tumour growth is still a daunting clinical problem leading to failure of the overall treatment regimens. The fundamental question is; could tumour cells be specifically sensitized to ionizing radiation (IR) by heat or factors exclusively expressed in tumour cells? One such factor, expressed in most tumours and silent in somatic cells, is telomerase. Biochemical and genetic studies have established an association between telomere maintenance and extended life span of human cells mediated through the expression of the catalytic sub-unit of telomerase (hTERT). Because of this, telomerase is an attractive target for inhibition in anti-cancer therapy. Telomeres are maintained by telomerase and hTERT interacts with heat shock protein (HSP) chaperones. This review will focus on the possible role of HSPs and telomerase in sensitizing tumour cells and, thus, enhancing the potential of targeted radiotherapy.

AB - The inability of radiotherapy to control tumour growth is still a daunting clinical problem leading to failure of the overall treatment regimens. The fundamental question is; could tumour cells be specifically sensitized to ionizing radiation (IR) by heat or factors exclusively expressed in tumour cells? One such factor, expressed in most tumours and silent in somatic cells, is telomerase. Biochemical and genetic studies have established an association between telomere maintenance and extended life span of human cells mediated through the expression of the catalytic sub-unit of telomerase (hTERT). Because of this, telomerase is an attractive target for inhibition in anti-cancer therapy. Telomeres are maintained by telomerase and hTERT interacts with heat shock protein (HSP) chaperones. This review will focus on the possible role of HSPs and telomerase in sensitizing tumour cells and, thus, enhancing the potential of targeted radiotherapy.

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KW - HSP90

KW - Telomerase

KW - Telomeres

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Role of HSPs and telomerase in radiotherapy

Abstract

Keywords

ASJC Scopus subject areas

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