@article{604c0cf81f244628b108e7c959e6b394,
title = "Role of HSD17B13 in the liver physiology and pathophysiology",
abstract = "17β-Hydroxysteroid dehydrogenases (HSD17Bs)comprise a large family of 15 members that are mainly involved in sex hormone metabolism. Some HSD17Bs enzymes also play key roles in cholesterol and fatty acid metabolism. Recent study showed that hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), an enzyme with unknown biological function, is a novel liver-specific lipid droplet (LD)-associated protein in mouse and humans. HSD17B13 expression is markedly upregulated in patients and mice with non-alcoholic fatty liver disease (NAFLD). Hepatic overexpression of HSD17B13 promotes lipid accumulation in the liver. In this review, we summarize recent progress regarding the role of HSD17B13 in the regulation of hepatic lipid homeostasis and discuss genetic, genomic and proteomic evidence supporting the pathogenic role of HSD17B13 in NAFLD. We also emphasize its potential as a biomarker of advanced liver disease, such as non-alcoholic steatohepatitis (NASH)and liver cancer.",
keywords = "Genome-wide association study, HSD17B13, Lipid droplets, NAFLD, Proteomics",
author = "Wen Su and Zhuo Mao and Yiao Liu and Xiaoyan Zhang and Weizhen Zhang and Gustafsson, {Jan Ake} and Youfei Guan",
note = "Funding Information: This study was supported by the grant 81500538/81500619/81870405 from the National Natural Science Foundation; The project was also funded by the Foundation of Shenzhen Basic Research Project (JCYJ20170818144501119), and the Natural Science Foundation of Shenzhen University (grant 2017093). JAG was supported by the Robert A. Welch Foundation (grant no E – 0004). Funding Information: This study was supported by the grant 81500538 / 81500619 / 81870405 from the National Natural Science Foundation ; The project was also funded by the Foundation of Shenzhen Basic Research Project ( JCYJ20170818144501119 ), and the Natural Science Foundation of Shenzhen University (grant 2017093 ). JAG was supported by the Robert A. Welch Foundation (grant no E – 0004 ). Funding Information: This study was supported by the grant 81500538/81500619/81870405 from the National Natural Science Foundation; The project was also funded by the Foundation of Shenzhen Basic Research Project (JCYJ20170818144501119), and the Natural Science Foundation of Shenzhen University (grant 2017093). JAG was supported by the Robert A. Welch Foundation (grant no E ? 0004). Publisher Copyright: {\textcopyright} 2018",
year = "2019",
month = jun,
day = "1",
doi = "10.1016/j.mce.2018.10.014",
language = "English (US)",
volume = "489",
pages = "119--125",
journal = "Molecular and cellular endocrinology",
issn = "0303-7207",
publisher = "Elsevier Ireland Ltd",
}