Role of HSD17B13 in the liver physiology and pathophysiology

Wen Su; Zhuo Mao; Yiao Liu; Xiaoyan Zhang; Weizhen Zhang; Jan Ake Gustafsson; Youfei Guan

doi:10.1016/j.mce.2018.10.014

Role of HSD17B13 in the liver physiology and pathophysiology

Wen Su, Zhuo Mao, Yiao Liu, Xiaoyan Zhang, Weizhen Zhang, Jan Ake Gustafsson, Youfei Guan

Research output: Contribution to journal › Review article

11 Scopus citations

Abstract

17β-Hydroxysteroid dehydrogenases (HSD17Bs)comprise a large family of 15 members that are mainly involved in sex hormone metabolism. Some HSD17Bs enzymes also play key roles in cholesterol and fatty acid metabolism. Recent study showed that hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), an enzyme with unknown biological function, is a novel liver-specific lipid droplet (LD)-associated protein in mouse and humans. HSD17B13 expression is markedly upregulated in patients and mice with non-alcoholic fatty liver disease (NAFLD). Hepatic overexpression of HSD17B13 promotes lipid accumulation in the liver. In this review, we summarize recent progress regarding the role of HSD17B13 in the regulation of hepatic lipid homeostasis and discuss genetic, genomic and proteomic evidence supporting the pathogenic role of HSD17B13 in NAFLD. We also emphasize its potential as a biomarker of advanced liver disease, such as non-alcoholic steatohepatitis (NASH)and liver cancer.

Original language	English (US)
Pages (from-to)	119-125
Number of pages	7
Journal	Molecular and cellular endocrinology
Volume	489
DOIs	https://doi.org/10.1016/j.mce.2018.10.014
State	Published - Jun 1 2019

Keywords

Genome-wide association study
HSD17B13
Lipid droplets
NAFLD
Proteomics

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Endocrinology

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title = "Role of HSD17B13 in the liver physiology and pathophysiology",

abstract = "17β-Hydroxysteroid dehydrogenases (HSD17Bs)comprise a large family of 15 members that are mainly involved in sex hormone metabolism. Some HSD17Bs enzymes also play key roles in cholesterol and fatty acid metabolism. Recent study showed that hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), an enzyme with unknown biological function, is a novel liver-specific lipid droplet (LD)-associated protein in mouse and humans. HSD17B13 expression is markedly upregulated in patients and mice with non-alcoholic fatty liver disease (NAFLD). Hepatic overexpression of HSD17B13 promotes lipid accumulation in the liver. In this review, we summarize recent progress regarding the role of HSD17B13 in the regulation of hepatic lipid homeostasis and discuss genetic, genomic and proteomic evidence supporting the pathogenic role of HSD17B13 in NAFLD. We also emphasize its potential as a biomarker of advanced liver disease, such as non-alcoholic steatohepatitis (NASH)and liver cancer.",

keywords = "Genome-wide association study, HSD17B13, Lipid droplets, NAFLD, Proteomics",

author = "Wen Su and Zhuo Mao and Yiao Liu and Xiaoyan Zhang and Weizhen Zhang and Gustafsson, {Jan Ake} and Youfei Guan",

year = "2019",

month = jun,

day = "1",

doi = "10.1016/j.mce.2018.10.014",

language = "English (US)",

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journal = "Molecular and cellular endocrinology",

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T1 - Role of HSD17B13 in the liver physiology and pathophysiology

AU - Su, Wen

AU - Mao, Zhuo

AU - Liu, Yiao

AU - Zhang, Xiaoyan

AU - Zhang, Weizhen

AU - Gustafsson, Jan Ake

AU - Guan, Youfei

PY - 2019/6/1

Y1 - 2019/6/1

N2 - 17β-Hydroxysteroid dehydrogenases (HSD17Bs)comprise a large family of 15 members that are mainly involved in sex hormone metabolism. Some HSD17Bs enzymes also play key roles in cholesterol and fatty acid metabolism. Recent study showed that hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), an enzyme with unknown biological function, is a novel liver-specific lipid droplet (LD)-associated protein in mouse and humans. HSD17B13 expression is markedly upregulated in patients and mice with non-alcoholic fatty liver disease (NAFLD). Hepatic overexpression of HSD17B13 promotes lipid accumulation in the liver. In this review, we summarize recent progress regarding the role of HSD17B13 in the regulation of hepatic lipid homeostasis and discuss genetic, genomic and proteomic evidence supporting the pathogenic role of HSD17B13 in NAFLD. We also emphasize its potential as a biomarker of advanced liver disease, such as non-alcoholic steatohepatitis (NASH)and liver cancer.

AB - 17β-Hydroxysteroid dehydrogenases (HSD17Bs)comprise a large family of 15 members that are mainly involved in sex hormone metabolism. Some HSD17Bs enzymes also play key roles in cholesterol and fatty acid metabolism. Recent study showed that hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), an enzyme with unknown biological function, is a novel liver-specific lipid droplet (LD)-associated protein in mouse and humans. HSD17B13 expression is markedly upregulated in patients and mice with non-alcoholic fatty liver disease (NAFLD). Hepatic overexpression of HSD17B13 promotes lipid accumulation in the liver. In this review, we summarize recent progress regarding the role of HSD17B13 in the regulation of hepatic lipid homeostasis and discuss genetic, genomic and proteomic evidence supporting the pathogenic role of HSD17B13 in NAFLD. We also emphasize its potential as a biomarker of advanced liver disease, such as non-alcoholic steatohepatitis (NASH)and liver cancer.

KW - Genome-wide association study

KW - HSD17B13

KW - Lipid droplets

KW - NAFLD

KW - Proteomics

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