Role of HSD17B13 in the liver physiology and pathophysiology

Wen Su, Zhuo Mao, Yiao Liu, Xiaoyan Zhang, Weizhen Zhang, Jan Ake Gustafsson, Youfei Guan

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

17β-Hydroxysteroid dehydrogenases (HSD17Bs)comprise a large family of 15 members that are mainly involved in sex hormone metabolism. Some HSD17Bs enzymes also play key roles in cholesterol and fatty acid metabolism. Recent study showed that hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), an enzyme with unknown biological function, is a novel liver-specific lipid droplet (LD)-associated protein in mouse and humans. HSD17B13 expression is markedly upregulated in patients and mice with non-alcoholic fatty liver disease (NAFLD). Hepatic overexpression of HSD17B13 promotes lipid accumulation in the liver. In this review, we summarize recent progress regarding the role of HSD17B13 in the regulation of hepatic lipid homeostasis and discuss genetic, genomic and proteomic evidence supporting the pathogenic role of HSD17B13 in NAFLD. We also emphasize its potential as a biomarker of advanced liver disease, such as non-alcoholic steatohepatitis (NASH)and liver cancer.

Original languageEnglish (US)
Pages (from-to)119-125
Number of pages7
JournalMolecular and cellular endocrinology
Volume489
DOIs
StatePublished - Jun 1 2019

Keywords

  • Genome-wide association study
  • HSD17B13
  • Lipid droplets
  • NAFLD
  • Proteomics

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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