Role of histone methylation in maintenance of genome integrity

Arjamand Mushtaq, Ulfat Syed Mir, Clayton R. Hunt, Shruti Pandita, Wajahat W. Tantray, Audesh Bhat, Raj K. Pandita, Mohammad Altaf, Tej K. Pandita

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Packaging of the eukaryotic genome with histone and other proteins forms a chromatin structure that regulates the outcome of all DNA mediated processes. The cellular pathways that ensure genomic stability detect and repair DNA damage through mechanisms that are critically dependent upon chromatin structures established by histones and, particularly upon transient histone post-translational modifications. Though subjected to a range of modifications, histone methylation is especially crucial for DNA damage repair, as the methylated histones often form platforms for subsequent repair protein binding at damaged sites. In this review, we highlight and discuss how histone methylation impacts the maintenance of genome integrity through effects related to DNA repair and repair pathway choice.

Original languageEnglish (US)
Article number1000
JournalGenes
Volume12
Issue number7
DOIs
StatePublished - Jul 2021

Keywords

  • DNA repair
  • Histone methylation
  • Homologous recombination
  • Non-homologous end joining

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Fingerprint

Dive into the research topics of 'Role of histone methylation in maintenance of genome integrity'. Together they form a unique fingerprint.

Cite this