@article{8b67becd9e3441c392a5bad23885ac00,
title = "Role of histone methylation in maintenance of genome integrity",
abstract = "Packaging of the eukaryotic genome with histone and other proteins forms a chromatin structure that regulates the outcome of all DNA mediated processes. The cellular pathways that ensure genomic stability detect and repair DNA damage through mechanisms that are critically dependent upon chromatin structures established by histones and, particularly upon transient histone post-translational modifications. Though subjected to a range of modifications, histone methylation is especially crucial for DNA damage repair, as the methylated histones often form platforms for subsequent repair protein binding at damaged sites. In this review, we highlight and discuss how histone methylation impacts the maintenance of genome integrity through effects related to DNA repair and repair pathway choice.",
keywords = "DNA repair, Histone methylation, Homologous recombination, Non-homologous end joining",
author = "Arjamand Mushtaq and Mir, {Ulfat Syed} and Hunt, {Clayton R.} and Shruti Pandita and Tantray, {Wajahat W.} and Audesh Bhat and Pandita, {Raj K.} and Mohammad Altaf and Pandita, {Tej K.}",
note = "Funding Information: Funding: T.K.P. acknowledges funds from National Institute of Health grants CA129537 and GM109768; M.A. acknowledges funds from the Department of Biotechnology, Govt. of India (BT/PR22348/BRB/10/1625/2017), DST-SERB (CRG/2020/003632) Govt. of India, RUSA-2.0, DST-PURSE, and DBT-BUILDER. Funding Information: T.K.P. acknowledges funds from National Institute of Health grants CA129537 and GM109768; M.A. acknowledges funds from the Department of Biotechnology, Govt. of India (BT/PR22348/BRB/10/1625/2017), DST-SERB (CRG/2020/003632) Govt. of India, RUSA-2.0, DSTPURSE, and DBT-BUILDER. Acknowledgments: We acknowledge Ishfaq A. Pandith for help in the preparation of the working models. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
month = jul,
doi = "10.3390/genes12071000",
language = "English (US)",
volume = "12",
journal = "Genes",
issn = "2073-4425",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "7",
}