TY - JOUR
T1 - Role of Glia-Derived Extracellular Vesicles in Neurodegenerative Diseases
AU - Li, Tianbai
AU - Tan, Xiang
AU - Li, Song
AU - Al-Nusaif, Murad
AU - Le, Weidong
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China (NSFC 81771521 and 82001483), the National Key R&D Program (2016YFC1306600), and Guangdong Provincial Key R&D Program (2018B030337001).
Publisher Copyright:
© Copyright © 2021 Li, Tan, Li, Al-Nusaif and Le.
PY - 2021/10/20
Y1 - 2021/10/20
N2 - Extracellular vesicles (EVs), as nano-sized vesicles secreted by almost all cells, have been recognized as the essential transmitter for cell-to-cell communication and participating in multiple biological processes. Neurodegenerative diseases (ND), such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, share common mechanisms of the aggregation and propagation of distinct pathologic proteins among cells in the nervous systems and neuroinflammatory reactions mediated by glia during the pathogenic process. This feature indicates the vital role of crosstalk between neurons and glia in the pathogenesis of ND. In recent years, glia-derived EVs have been investigated as potential mediators of signals between neurons and glia, which provides a new direction and strategy for understanding ND. By a comprehensive summary, it can be concluded that glia-derived EVs have both a beneficial and/or a detrimental effect in the process of ND. Therefore, this review article conveys the role of glia-derived EVs in the pathogenesis of ND and raises current limitations of their potential application in the diagnosis and treatment of ND.
AB - Extracellular vesicles (EVs), as nano-sized vesicles secreted by almost all cells, have been recognized as the essential transmitter for cell-to-cell communication and participating in multiple biological processes. Neurodegenerative diseases (ND), such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, share common mechanisms of the aggregation and propagation of distinct pathologic proteins among cells in the nervous systems and neuroinflammatory reactions mediated by glia during the pathogenic process. This feature indicates the vital role of crosstalk between neurons and glia in the pathogenesis of ND. In recent years, glia-derived EVs have been investigated as potential mediators of signals between neurons and glia, which provides a new direction and strategy for understanding ND. By a comprehensive summary, it can be concluded that glia-derived EVs have both a beneficial and/or a detrimental effect in the process of ND. Therefore, this review article conveys the role of glia-derived EVs in the pathogenesis of ND and raises current limitations of their potential application in the diagnosis and treatment of ND.
KW - astrocyte
KW - extracellular vesicles
KW - glia
KW - microglia
KW - neurodegenerative diseases
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U2 - 10.3389/fnagi.2021.765395
DO - 10.3389/fnagi.2021.765395
M3 - Review article
C2 - 34744700
AN - SCOPUS:85118657214
SN - 1663-4365
VL - 13
SP - 765395
JO - Frontiers in Aging Neuroscience
JF - Frontiers in Aging Neuroscience
M1 - 765395
ER -