Role of Cdc6 During Oogenesis and Early Embryo Development in Mouse and Xenopus laevis

Ewa Borsuk, Joanna Jachowicz, Malgorzata Kloc, Jean Pierre Tassan, Jacek Z. Kubiak

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cdc6 is an important player in cell cycle regulation. It is involved in the regulation of both S-phase and M-phase. Its role during oogenesis is crucial for repression of the S-phase between the first and the second meiotic M-phases, and it also regulates, via CDK1 inhibition, the M-phase entry and exit. This is of special importance for the reactivation of the major M-phase-regulating kinase CDK1 (Cyclin-Dependent Kinase 1) in oocytes entering metaphase II of meiosis and in embryo cleavage divisions, in which precise timing allows coordination between cell cycle events and developmental program of the embryo. In this chapter, we discuss the role of Cdc6 protein in oocytes and early embryos.

Original languageEnglish (US)
Title of host publicationResults and Problems in Cell Differentiation
PublisherSpringer-Verlag
Pages201-211
Number of pages11
Volume59
ISBN (Electronic)18610412
ISBN (Print)00801844
DOIs
StatePublished - Mar 1 2017

Publication series

NameResults and Problems in Cell Differentiation
Volume59
ISSN (Print)0080-1844
ISSN (Electronic)1861-0412

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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