Abstract
Chondrocyte differentiation in the growth plate is an important process for the longitudinal growth of endochondral bones. Sox9 and Runx2 are the most often-studied transcriptional regulators of the chondrocyte differentiation process, but the importance of additional factors is also becoming apparent. Mafs are a subfamily of the basic ZIP (bZIP) transcription factor superfamily, which act as key regulators of tissue-specific gene expression and terminal differentiation in many tissues. There is increasing evidence that c-Maf and its splicing variant Lc-Maf play a role in chondrocyte differentiation in a temporal-spatial manner. This review summarizes the functions of c-Maf in chondrocyte differentiation and discusses the possible role of c-Maf in osteoarthritis progression.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 27-35 |
| Number of pages | 9 |
| Journal | Cartilage |
| Volume | 2 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2011 |
Keywords
- Articular cartilage
- Chondrocytes
- Chondrogenesis
- Mesenchymal stem cells
- Signaling molecules
ASJC Scopus subject areas
- Immunology and Allergy
- Biomedical Engineering
- Physical Therapy, Sports Therapy and Rehabilitation
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