Role of c-maf in chondrocyte differentiation: A review

Eunmee Hong; Paul E. di Cesare; Dominik R. Haudenschild

doi:10.1177/1947603510377464

Role of c-maf in chondrocyte differentiation: A review

Eunmee Hong, Paul E. di Cesare, Dominik R. Haudenschild

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Chondrocyte differentiation in the growth plate is an important process for the longitudinal growth of endochondral bones. Sox9 and Runx2 are the most often-studied transcriptional regulators of the chondrocyte differentiation process, but the importance of additional factors is also becoming apparent. Mafs are a subfamily of the basic ZIP (bZIP) transcription factor superfamily, which act as key regulators of tissue-specific gene expression and terminal differentiation in many tissues. There is increasing evidence that c-Maf and its splicing variant Lc-Maf play a role in chondrocyte differentiation in a temporal-spatial manner. This review summarizes the functions of c-Maf in chondrocyte differentiation and discusses the possible role of c-Maf in osteoarthritis progression.

Original language	English (US)
Pages (from-to)	27-35
Number of pages	9
Journal	Cartilage
Volume	2
Issue number	1
DOIs	https://doi.org/10.1177/1947603510377464
State	Published - Jan 2011

Keywords

Articular cartilage
Chondrocytes
Chondrogenesis
Mesenchymal stem cells
Signaling molecules

ASJC Scopus subject areas

Immunology and Allergy
Biomedical Engineering
Physical Therapy, Sports Therapy and Rehabilitation

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10.1177/1947603510377464

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abstract = "Chondrocyte differentiation in the growth plate is an important process for the longitudinal growth of endochondral bones. Sox9 and Runx2 are the most often-studied transcriptional regulators of the chondrocyte differentiation process, but the importance of additional factors is also becoming apparent. Mafs are a subfamily of the basic ZIP (bZIP) transcription factor superfamily, which act as key regulators of tissue-specific gene expression and terminal differentiation in many tissues. There is increasing evidence that c-Maf and its splicing variant Lc-Maf play a role in chondrocyte differentiation in a temporal-spatial manner. This review summarizes the functions of c-Maf in chondrocyte differentiation and discusses the possible role of c-Maf in osteoarthritis progression.",

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AU - Haudenschild, Dominik R.

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N2 - Chondrocyte differentiation in the growth plate is an important process for the longitudinal growth of endochondral bones. Sox9 and Runx2 are the most often-studied transcriptional regulators of the chondrocyte differentiation process, but the importance of additional factors is also becoming apparent. Mafs are a subfamily of the basic ZIP (bZIP) transcription factor superfamily, which act as key regulators of tissue-specific gene expression and terminal differentiation in many tissues. There is increasing evidence that c-Maf and its splicing variant Lc-Maf play a role in chondrocyte differentiation in a temporal-spatial manner. This review summarizes the functions of c-Maf in chondrocyte differentiation and discusses the possible role of c-Maf in osteoarthritis progression.

AB - Chondrocyte differentiation in the growth plate is an important process for the longitudinal growth of endochondral bones. Sox9 and Runx2 are the most often-studied transcriptional regulators of the chondrocyte differentiation process, but the importance of additional factors is also becoming apparent. Mafs are a subfamily of the basic ZIP (bZIP) transcription factor superfamily, which act as key regulators of tissue-specific gene expression and terminal differentiation in many tissues. There is increasing evidence that c-Maf and its splicing variant Lc-Maf play a role in chondrocyte differentiation in a temporal-spatial manner. This review summarizes the functions of c-Maf in chondrocyte differentiation and discusses the possible role of c-Maf in osteoarthritis progression.

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KW - Chondrocytes

KW - Chondrogenesis

KW - Mesenchymal stem cells

KW - Signaling molecules

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Role of c-maf in chondrocyte differentiation: A review

Abstract

Keywords

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