Role of Adaptive Immunity in the Development and Progression of Heart Failure: New Evidence

Luis Sánchez-Trujillo, Eduardo Vázquez-Garza, Elena C. Castillo, Gerardo García-Rivas, Guillermo Torre-Amione

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

Heart failure (HF) is considered the endpoint of a variety of cardiac diseases, which are the leading cause of death in adults and considered a growing pandemic worldwide. Independent of the initial form of cardiac injury, there is evidence linking the involvement of the immune system. In HF there is evidence of the participation of TH1, and TH17 cells, which account for sustained pathological chronic inflammation, cell migration, and the induction of specific pathological phenotypes of mononuclear cells. Of equal or even higher relevance are the B lymphocyte activation mechanisms that include production of pro-inflammatory cytokines, chemokines, and cardiac autoantibodies with or without activation of the complement proteins. Both of these unbalanced T- and B-cell pathways of the adaptive immune system are associated with cardiomyocyte death and tissue remodeling by fibrosis leading to a dysfunctional heart. At this time, therapy with neutralizing antibodies and the use of anti-cytokine immunomodulators to counteract the immune system effects have reached a plateau of mixed results in clinical trials. Nevertheless, recent evidence showed promising results in animal models that suggest that modulation of the adaptive immune system cells more than some of their effector molecules could have benefits in HF patients. This review summarizes the role of the adaptive immunity cells in HF, considering the sustained activation of adaptive immune system as a potential contributor to disease progression in humans and experimental models where its regulation provides a new therapeutic target.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalArchives of Medical Research
Volume48
Issue number1
DOIs
StatePublished - Jan 2017

Keywords

  • Adaptive immunity
  • Auto-antibody
  • B cells
  • Heart failure
  • T cells

ASJC Scopus subject areas

  • Medicine(all)

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