Role of 14-3-3 protein and oxidative stress in diabetic cardiomyopathy

K. Watanabe, R. A. Thandavarayan, N. Gurusamy, S. Zhang, A. J. Muslin, K. Suzuki, H. Tachikawa, M. Kodama, Y. Aizawa

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Cardiovascular disease is a leading cause of death worldwide. Diabetes mellitus is a well-known and important risk factor for cardiovascular diseases. The occurrence of diabetic cardiomyopathy is independent of hypertension, coronary artery disease, or any other known cardiac diseases. There is growing evidence that excess generation of highly reactive free radicals, largely due to hyperglycemia, causes oxidative stress, which further exacerbates the development and progression of diabetes and its complications. Diabetic cardiomyopathy is characterized by morphologic and structural changes in the myocardium and coronary vasculature mediated by the activation of various signaling pathways. Myocardial apoptosis, hypertrophy and fibrosis are the most frequently proposed mechanisms to explain cardiac changes in diabetic cardiomyopathy. Mammalian 14-3-3 proteins are dimeric phosphoserine-binding proteins that participate in signal transduction and regulate several aspects of cellular biochemistry. 14-3-3 protein regulates diabetic cardiomyopathy via multiple signaling pathways. This review focuses on emerging evidence suggesting that 14-3-3 protein plays a key role in the pathogenesis of the cardiovascular complications of diabetes, which underlie the development and progression of diabetic cardiomyopathy.

Original languageEnglish (US)
Pages (from-to)277-287
Number of pages11
JournalActa Physiologica Hungarica
Issue number3
StatePublished - 2009


  • 14-3-3 protein
  • Apoptosis
  • Cardiomyopathy
  • Diabetes mellitus
  • Glycogen synthase kinase 3 beta
  • Hypertrophy
  • Mitogen-activated protein kinase
  • Oxidative stress
  • Protein kinase C

ASJC Scopus subject areas

  • Physiology (medical)


Dive into the research topics of 'Role of 14-3-3 protein and oxidative stress in diabetic cardiomyopathy'. Together they form a unique fingerprint.

Cite this