Abstract
Basal transcriptional from the human RNA apolymerase III U6 promoter depends on a TATA box that recruits the TATA box-binding protein (TBP) and a proximal sequence element that recruits the small nuclear RNA (snRNA)- activating protein complex (SNAP). TBP consists of a conserved carboxyl- terminal domain that performs all known function of the protein and a conconserved amino-terminal region of unknown function. Here, the amino- terminals region is shown to down-regulate binding of TBP to the U6 TATA box, mediate cooperative binding with SNAP to the U6 promoter, and enhance U6 transcription.
Original language | English (US) |
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Pages (from-to) | 1136-1140 |
Number of pages | 5 |
Journal | Science |
Volume | 275 |
Issue number | 5303 |
DOIs | |
State | Published - Feb 21 1997 |
ASJC Scopus subject areas
- General