Robustness of validation criteria in the College of American Pathologists Interlaboratory Comparison Program in Cervicovaginal Cytology

Andrew A. Renshaw, Molly K. Walsh, Barbara Blond, Ann T. Moriarty, Dina R. Mody, Terence J. Colgan

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Context. - Field validation of slides used in gynecologic cytology proficiency testing has surfaced as an important issue. Although the precision of diagnoses in peer-reviewed educational programs has been examined, the robustness of the validation criteria for specific types of interpretations used in proficiency testing has not been previously studied. Objective. - To evaluate the robustness of validation criteria for slides entering an educational slide program. Design. - We reviewed the results of the College of American Pathologists Interlaboratory Comparison Program in Cervicovaginal Cytology and compared the robustness of validation criteria for different reference diagnoses, using a total of 16948 circulating slides. Results. - Validation criteria could be divided into 2 significantly different groups. The criteria for herpes, Trichomonas, squamous cell carcinoma, and adenocarcinoma were significantly more robust than the diagnoses of unsatisfactory; negative for intraepithelial lesion and malignancy, not otherwise specified; low-grade squamous intraepithelial lesion; and high-grade squamous intraepithelial lesion (P < .001). Conclusions. - The validation criteria used in the College of American Pathologists Interlaboratory Comparison Program in Cervicovaginal Cytology show 2 different levels of robustness or redundancy. These results have implications for the design of fair proficiency tests. Proficiency testing can be designed with the necessary number of reviews needed for slide validation.

Original languageEnglish (US)
Pages (from-to)1119-1122
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Volume130
Issue number8
StatePublished - Aug 1 2006

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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