RNA localization and its role in the spatially restricted protein synthesis

Małgorzata Kloc, Szczepan M. Biliński

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

RNA localization is an evolutionarily conserved phenomenon that occurs in uni- and multi-cellular animal and plant species. Localized RNA plays a role in the establishment of cell polarity and/or the determination of cell fate. In recent years, it became evident that the major function of RNA localization is the creation of a high concentration of proteins in specific cellular compartments. The movement of RNA involves interactions between targeting signals within the RNA molecule, cytoskeleton, and molecular motors. Translocating RNA must be translationally silent, and on-site translation at the destination site requires a de-repression mechanism. This is probably achieved by sequestering RNA and the regulators of translation within the multiprotein RNP complexes that co-translocate all the components to the ultimate destination within the cell.

Original languageEnglish (US)
Pages (from-to)3-11
Number of pages9
JournalFolia Histochemica et Cytobiologica
Volume41
Issue number1
StatePublished - 2003

Keywords

  • Cell-fate determination
  • Germ cells
  • RNA localization
  • RNA transport
  • Translation

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

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