RNA Interference

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

RNA interference (RNAi) is a broad term that can refer to the effects of short or long noncoding RNAs on expression of individual or families of protein-encoding genes. This article is focused on one aspect of RNAi, namely the use of short double-stranded RNAs (dsRNAs) or their precursors that exhibit sequence-specific binding with target mRNAs, resulting in posttranscriptional gene silencing. This form of RNAi has revolutionized studies on gene pathways and networks and is a promising new approach for clinical treatment of various diseases including cancer.

Original languageEnglish (US)
Title of host publicationBrenner's Encyclopedia of Genetics
Subtitle of host publicationSecond Edition
PublisherElsevier
Pages288-289
Number of pages2
ISBN (Electronic)9780080961569
ISBN (Print)9780123749840
DOIs
StatePublished - Feb 27 2013

Keywords

  • Clinical applications
  • DsRNA
  • Inhibition
  • MicroRNAs
  • Noncoding RNAs
  • RISC
  • RNAi
  • Screening
  • SiRNA
  • Suppression

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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