Abstract
RNA interference (RNAi) is a broad term that can refer to the effects of short or long noncoding RNAs on expression of individual or families of protein-encoding genes. This article is focused on one aspect of RNAi, namely the use of short double-stranded RNAs (dsRNAs) or their precursors that exhibit sequence-specific binding with target mRNAs, resulting in posttranscriptional gene silencing. This form of RNAi has revolutionized studies on gene pathways and networks and is a promising new approach for clinical treatment of various diseases including cancer.
| Original language | English (US) |
|---|---|
| Title of host publication | Brenner's Encyclopedia of Genetics |
| Subtitle of host publication | Second Edition |
| Publisher | Elsevier |
| Pages | 288-289 |
| Number of pages | 2 |
| ISBN (Electronic) | 9780080961569 |
| ISBN (Print) | 9780123749840 |
| DOIs | |
| State | Published - Feb 27 2013 |
Keywords
- Clinical applications
- DsRNA
- Inhibition
- MicroRNAs
- Noncoding RNAs
- RISC
- RNAi
- Screening
- SiRNA
- Suppression
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)