RNA Interference

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


RNA interference (RNAi) is a broad term that can refer to the effects of short or long noncoding RNAs on expression of individual or families of protein-encoding genes. This article is focused on one aspect of RNAi, namely the use of short double-stranded RNAs (dsRNAs) or their precursors that exhibit sequence-specific binding with target mRNAs, resulting in posttranscriptional gene silencing. This form of RNAi has revolutionized studies on gene pathways and networks and is a promising new approach for clinical treatment of various diseases including cancer.

Original languageEnglish (US)
Title of host publicationBrenner's Encyclopedia of Genetics
Subtitle of host publicationSecond Edition
Number of pages2
ISBN (Electronic)9780080961569
ISBN (Print)9780123749840
StatePublished - Feb 27 2013


  • Clinical applications
  • DsRNA
  • Inhibition
  • MicroRNAs
  • Noncoding RNAs
  • RISC
  • RNAi
  • Screening
  • SiRNA
  • Suppression

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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