Risk Stratification for Primary Prevention of Coronary Artery Disease: Roles of C-Reactive Protein and Coronary Artery Calcium

Waqas T. Qureshi; Jamal S. Rana; Joseph Yeboah; Usama bin Nasir; Mouaz H. Al-Mallah

doi:10.1007/s11886-015-0666-9

Risk Stratification for Primary Prevention of Coronary Artery Disease: Roles of C-Reactive Protein and Coronary Artery Calcium

Waqas T. Qureshi, Jamal S. Rana, Joseph Yeboah, Usama bin Nasir, Mouaz H. Al-Mallah

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

Risk stratification of individuals at risk for atherosclerotic cardiovascular disease (ASCVD) plays an important role in primary prevention of cardiovascular disease. In addition to risk scores derived from conventional cardiovascular risk factors, high sensitivity C-reactive protein (hs-CRP) and coronary artery calcium (CAC) have emerged as two of the widely accepted non traditional risk factors for atherosclerotic disease that have shown incremental prognostic value in predicting cardiovascular events. This review systematically assesses the role of hs-CRP and CAC in various studies and demonstrates meta-analyses of the incremental prognostic value of hs-CRP and CAC in identifying patients at risk of future CVD events. Compared with this, CAC showed better incremental prognostic value and might be a better indicator of ASCVD risk in asymptomatic adults.

Original language	English (US)
Article number	110
Journal	Current Cardiology Reports
Volume	17
Issue number	12
DOIs	https://doi.org/10.1007/s11886-015-0666-9
State	Published - Dec 1 2015
Externally published	Yes

Keywords

Cholesterol treatment
Coronary artery calcium
Epidemiology
High sensitivity C reactive protein
Review
Risk factors
Statin therapy

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1007/s11886-015-0666-9

Cite this

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title = "Risk Stratification for Primary Prevention of Coronary Artery Disease: Roles of C-Reactive Protein and Coronary Artery Calcium",

abstract = "Risk stratification of individuals at risk for atherosclerotic cardiovascular disease (ASCVD) plays an important role in primary prevention of cardiovascular disease. In addition to risk scores derived from conventional cardiovascular risk factors, high sensitivity C-reactive protein (hs-CRP) and coronary artery calcium (CAC) have emerged as two of the widely accepted non traditional risk factors for atherosclerotic disease that have shown incremental prognostic value in predicting cardiovascular events. This review systematically assesses the role of hs-CRP and CAC in various studies and demonstrates meta-analyses of the incremental prognostic value of hs-CRP and CAC in identifying patients at risk of future CVD events. Compared with this, CAC showed better incremental prognostic value and might be a better indicator of ASCVD risk in asymptomatic adults.",

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doi = "10.1007/s11886-015-0666-9",

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T2 - Roles of C-Reactive Protein and Coronary Artery Calcium

AU - Qureshi, Waqas T.

AU - Rana, Jamal S.

AU - Yeboah, Joseph

AU - bin Nasir, Usama

AU - Al-Mallah, Mouaz H.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Risk stratification of individuals at risk for atherosclerotic cardiovascular disease (ASCVD) plays an important role in primary prevention of cardiovascular disease. In addition to risk scores derived from conventional cardiovascular risk factors, high sensitivity C-reactive protein (hs-CRP) and coronary artery calcium (CAC) have emerged as two of the widely accepted non traditional risk factors for atherosclerotic disease that have shown incremental prognostic value in predicting cardiovascular events. This review systematically assesses the role of hs-CRP and CAC in various studies and demonstrates meta-analyses of the incremental prognostic value of hs-CRP and CAC in identifying patients at risk of future CVD events. Compared with this, CAC showed better incremental prognostic value and might be a better indicator of ASCVD risk in asymptomatic adults.

AB - Risk stratification of individuals at risk for atherosclerotic cardiovascular disease (ASCVD) plays an important role in primary prevention of cardiovascular disease. In addition to risk scores derived from conventional cardiovascular risk factors, high sensitivity C-reactive protein (hs-CRP) and coronary artery calcium (CAC) have emerged as two of the widely accepted non traditional risk factors for atherosclerotic disease that have shown incremental prognostic value in predicting cardiovascular events. This review systematically assesses the role of hs-CRP and CAC in various studies and demonstrates meta-analyses of the incremental prognostic value of hs-CRP and CAC in identifying patients at risk of future CVD events. Compared with this, CAC showed better incremental prognostic value and might be a better indicator of ASCVD risk in asymptomatic adults.

KW - Cholesterol treatment

KW - Coronary artery calcium

KW - Epidemiology

KW - High sensitivity C reactive protein

KW - Review

KW - Risk factors

KW - Statin therapy

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Risk Stratification for Primary Prevention of Coronary Artery Disease: Roles of C-Reactive Protein and Coronary Artery Calcium

Abstract

Keywords

ASJC Scopus subject areas

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