Risk of acute myeloid leukemia and myelodysplastic syndrome after autotransplants for lymphomas and plasma cell myeloma

Tomas Radivoyevitch; Robert M. Dean; Bronwen E. Shaw; Ruta Brazauskas; Heather R. Tecca; Remco J. Molenaar; Minoo Battiwalla; Bipin N. Savani; Mary E.D. Flowers; Kenneth R. Cooke; Betty K. Hamilton; Matt Kalaycio; Jaroslaw P. Maciejewski; Ibrahim Ahmed; Görgün Akpek; Ashish Bajel; David Buchbinder; Jean Yves Cahn; Anita D'Souza; Andrew Daly; Zachariah DeFilipp; Siddhartha Ganguly; Mehdi Hamadani; Robert J. Hayashi; Peiman Hematti; Yoshihiro Inamoto; Nandita Khera; Tamila Kindwall-Keller; Heather Landau; Hillard Lazarus; Navneet S. Majhail; David I. Marks; Richard F. Olsson; Sachiko Seo; Amir Steinberg; Basem M. William; Baldeep Wirk; Jean A. Yared; Mahmoud Aljurf; Muneer H. Abidi; Heather Allewelt; Amer Beitinjaneh; Rachel Cook; Robert F. Cornell; Joseph W. Fay; Gregory Hale; Jennifer Holter Chakrabarty; Sonata Jodele; Kimberly A. Kasow; Anuj Mahindra; Adriana K. Malone; Uday Popat; J. Douglas Rizzo; Harry C. Schouten; Anne B. Warwick; William A. Wood; Mikkael A. Sekeres; Mark R. Litzow; Robert P. Gale; Shahrukh K. Hashmi

doi:10.1016/j.leukres.2018.07.016

Risk of acute myeloid leukemia and myelodysplastic syndrome after autotransplants for lymphomas and plasma cell myeloma

Tomas Radivoyevitch, Robert M. Dean, Bronwen E. Shaw, Ruta Brazauskas, Heather R. Tecca, Remco J. Molenaar, Minoo Battiwalla, Bipin N. Savani, Mary E.D. Flowers, Kenneth R. Cooke, Betty K. Hamilton, Matt Kalaycio, Jaroslaw P. Maciejewski, Ibrahim Ahmed, Görgün Akpek, Ashish Bajel, David Buchbinder, Jean Yves Cahn, Anita D'Souza, Andrew DalyZachariah DeFilipp, Siddhartha Ganguly, Mehdi Hamadani, Robert J. Hayashi, Peiman Hematti, Yoshihiro Inamoto, Nandita Khera, Tamila Kindwall-Keller, Heather Landau, Hillard Lazarus, Navneet S. Majhail, David I. Marks, Richard F. Olsson, Sachiko Seo, Amir Steinberg, Basem M. William, Baldeep Wirk, Jean A. Yared, Mahmoud Aljurf, Muneer H. Abidi, Heather Allewelt, Amer Beitinjaneh, Rachel Cook, Robert F. Cornell, Joseph W. Fay, Gregory Hale, Jennifer Holter Chakrabarty, Sonata Jodele, Kimberly A. Kasow, Anuj Mahindra, Adriana K. Malone, Uday Popat, J. Douglas Rizzo, Harry C. Schouten, Anne B. Warwick, William A. Wood, Mikkael A. Sekeres, Mark R. Litzow, Robert P. Gale, Shahrukh K. Hashmi

Houston Methodist

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Background: Exposures to DNA-damaging drugs and ionizing radiations increase risks of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Methods: 9028 recipients of hematopoietic cell autotransplants (1995–2010) for Hodgkin lymphoma (HL; n = 916), non-Hodgkin lymphoma (NHL; n = 3546) and plasma cell myeloma (PCM; n = 4566), reported to the CIBMTR, were analyzed for risk of subsequent AML or MDS. Results: 335 MDS/AML cases were diagnosed posttransplant (3.7%). Variables associated with an increased risk for AML or MDS in multivariate analyses were: (1) conditioning with total body radiation versus chemotherapy alone for HL (HR = 4.0; 95% confidence interval [1.4, 11.6]) and NHL (HR = 2.5 [1.1, 2.5]); (2) ≥3 versus 1 line of chemotherapy for NHL (HR = 1.9 [1.3, 2.8]); and (3) subjects with NHL transplanted in 2005–2010 versus 1995–1999 (HR = 2.1 [1.5, 3.1]). Using Surveillance, Epidemiology and End Results (SEER) data, we found risks for AML/MDS in HL, NHL and PCM to be 5–10 times the background rate. In contrast, relative risks were 10–50 for AML and approximately 100 for MDS in the autotransplant cohort. Conclusions: There are substantial risks of AML and MDS after autotransplants for HL, NHL and PCM.

Original language	English (US)
Pages (from-to)	130-136
Number of pages	7
Journal	Leukemia Research
Volume	74
DOIs	https://doi.org/10.1016/j.leukres.2018.07.016
State	Published - Nov 2018

Keywords

AML
Autotransplant
CIBMTR
MDS
New cancers
SEER
Therapy-related

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/j.leukres.2018.07.016

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Radivoyevitch, T., Dean, R. M., Shaw, B. E., Brazauskas, R., Tecca, H. R., Molenaar, R. J., Battiwalla, M., Savani, B. N., Flowers, M. E. D., Cooke, K. R., Hamilton, B. K., Kalaycio, M., Maciejewski, J. P., Ahmed, I., Akpek, G., Bajel, A., Buchbinder, D., Cahn, J. Y., D'Souza, A., ... Hashmi, S. K. (2018). Risk of acute myeloid leukemia and myelodysplastic syndrome after autotransplants for lymphomas and plasma cell myeloma. Leukemia Research, 74, 130-136. https://doi.org/10.1016/j.leukres.2018.07.016

Radivoyevitch, T, Dean, RM, Shaw, BE, Brazauskas, R, Tecca, HR, Molenaar, RJ, Battiwalla, M, Savani, BN, Flowers, MED, Cooke, KR, Hamilton, BK, Kalaycio, M, Maciejewski, JP, Ahmed, I, Akpek, G, Bajel, A, Buchbinder, D, Cahn, JY, D'Souza, A, Daly, A, DeFilipp, Z, Ganguly, S, Hamadani, M, Hayashi, RJ, Hematti, P, Inamoto, Y, Khera, N, Kindwall-Keller, T, Landau, H, Lazarus, H, Majhail, NS, Marks, DI, Olsson, RF, Seo, S, Steinberg, A, William, BM, Wirk, B, Yared, JA, Aljurf, M, Abidi, MH, Allewelt, H, Beitinjaneh, A, Cook, R, Cornell, RF, Fay, JW, Hale, G, Chakrabarty, JH, Jodele, S, Kasow, KA, Mahindra, A, Malone, AK, Popat, U, Rizzo, JD, Schouten, HC, Warwick, AB, Wood, WA, Sekeres, MA, Litzow, MR, Gale, RP & Hashmi, SK 2018, 'Risk of acute myeloid leukemia and myelodysplastic syndrome after autotransplants for lymphomas and plasma cell myeloma', Leukemia Research, vol. 74, pp. 130-136. https://doi.org/10.1016/j.leukres.2018.07.016

@article{80b6ffefbdf640118d8c8becd544431a,

title = "Risk of acute myeloid leukemia and myelodysplastic syndrome after autotransplants for lymphomas and plasma cell myeloma",

abstract = "Background: Exposures to DNA-damaging drugs and ionizing radiations increase risks of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Methods: 9028 recipients of hematopoietic cell autotransplants (1995–2010) for Hodgkin lymphoma (HL; n = 916), non-Hodgkin lymphoma (NHL; n = 3546) and plasma cell myeloma (PCM; n = 4566), reported to the CIBMTR, were analyzed for risk of subsequent AML or MDS. Results: 335 MDS/AML cases were diagnosed posttransplant (3.7%). Variables associated with an increased risk for AML or MDS in multivariate analyses were: (1) conditioning with total body radiation versus chemotherapy alone for HL (HR = 4.0; 95% confidence interval [1.4, 11.6]) and NHL (HR = 2.5 [1.1, 2.5]); (2) ≥3 versus 1 line of chemotherapy for NHL (HR = 1.9 [1.3, 2.8]); and (3) subjects with NHL transplanted in 2005–2010 versus 1995–1999 (HR = 2.1 [1.5, 3.1]). Using Surveillance, Epidemiology and End Results (SEER) data, we found risks for AML/MDS in HL, NHL and PCM to be 5–10 times the background rate. In contrast, relative risks were 10–50 for AML and approximately 100 for MDS in the autotransplant cohort. Conclusions: There are substantial risks of AML and MDS after autotransplants for HL, NHL and PCM.",

keywords = "AML, Autotransplant, CIBMTR, MDS, New cancers, SEER, Therapy-related",

author = "Tomas Radivoyevitch and Dean, {Robert M.} and Shaw, {Bronwen E.} and Ruta Brazauskas and Tecca, {Heather R.} and Molenaar, {Remco J.} and Minoo Battiwalla and Savani, {Bipin N.} and Flowers, {Mary E.D.} and Cooke, {Kenneth R.} and Hamilton, {Betty K.} and Matt Kalaycio and Maciejewski, {Jaroslaw P.} and Ibrahim Ahmed and G{\"o}rg{\"u}n Akpek and Ashish Bajel and David Buchbinder and Cahn, {Jean Yves} and Anita D'Souza and Andrew Daly and Zachariah DeFilipp and Siddhartha Ganguly and Mehdi Hamadani and Hayashi, {Robert J.} and Peiman Hematti and Yoshihiro Inamoto and Nandita Khera and Tamila Kindwall-Keller and Heather Landau and Hillard Lazarus and Majhail, {Navneet S.} and Marks, {David I.} and Olsson, {Richard F.} and Sachiko Seo and Amir Steinberg and William, {Basem M.} and Baldeep Wirk and Yared, {Jean A.} and Mahmoud Aljurf and Abidi, {Muneer H.} and Heather Allewelt and Amer Beitinjaneh and Rachel Cook and Cornell, {Robert F.} and Fay, {Joseph W.} and Gregory Hale and Chakrabarty, {Jennifer Holter} and Sonata Jodele and Kasow, {Kimberly A.} and Anuj Mahindra and Malone, {Adriana K.} and Uday Popat and Rizzo, {J. Douglas} and Schouten, {Harry C.} and Warwick, {Anne B.} and Wood, {William A.} and Sekeres, {Mikkael A.} and Litzow, {Mark R.} and Gale, {Robert P.} and Hashmi, {Shahrukh K.}",

note = "Publisher Copyright: {\textcopyright} 2018",

year = "2018",

month = nov,

doi = "10.1016/j.leukres.2018.07.016",

language = "English (US)",

volume = "74",

pages = "130--136",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Risk of acute myeloid leukemia and myelodysplastic syndrome after autotransplants for lymphomas and plasma cell myeloma

AU - Radivoyevitch, Tomas

AU - Dean, Robert M.

AU - Shaw, Bronwen E.

AU - Brazauskas, Ruta

AU - Tecca, Heather R.

AU - Molenaar, Remco J.

AU - Battiwalla, Minoo

AU - Savani, Bipin N.

AU - Flowers, Mary E.D.

AU - Cooke, Kenneth R.

AU - Hamilton, Betty K.

AU - Kalaycio, Matt

AU - Maciejewski, Jaroslaw P.

AU - Ahmed, Ibrahim

AU - Akpek, Görgün

AU - Bajel, Ashish

AU - Buchbinder, David

AU - Cahn, Jean Yves

AU - D'Souza, Anita

AU - Daly, Andrew

AU - DeFilipp, Zachariah

AU - Ganguly, Siddhartha

AU - Hamadani, Mehdi

AU - Hayashi, Robert J.

AU - Hematti, Peiman

AU - Inamoto, Yoshihiro

AU - Khera, Nandita

AU - Kindwall-Keller, Tamila

AU - Landau, Heather

AU - Lazarus, Hillard

AU - Majhail, Navneet S.

AU - Marks, David I.

AU - Olsson, Richard F.

AU - Seo, Sachiko

AU - Steinberg, Amir

AU - William, Basem M.

AU - Wirk, Baldeep

AU - Yared, Jean A.

AU - Aljurf, Mahmoud

AU - Abidi, Muneer H.

AU - Allewelt, Heather

AU - Beitinjaneh, Amer

AU - Cook, Rachel

AU - Cornell, Robert F.

AU - Fay, Joseph W.

AU - Hale, Gregory

AU - Chakrabarty, Jennifer Holter

AU - Jodele, Sonata

AU - Kasow, Kimberly A.

AU - Mahindra, Anuj

AU - Malone, Adriana K.

AU - Popat, Uday

AU - Rizzo, J. Douglas

AU - Schouten, Harry C.

AU - Warwick, Anne B.

AU - Wood, William A.

AU - Sekeres, Mikkael A.

AU - Litzow, Mark R.

AU - Gale, Robert P.

AU - Hashmi, Shahrukh K.

PY - 2018/11

Y1 - 2018/11

N2 - Background: Exposures to DNA-damaging drugs and ionizing radiations increase risks of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Methods: 9028 recipients of hematopoietic cell autotransplants (1995–2010) for Hodgkin lymphoma (HL; n = 916), non-Hodgkin lymphoma (NHL; n = 3546) and plasma cell myeloma (PCM; n = 4566), reported to the CIBMTR, were analyzed for risk of subsequent AML or MDS. Results: 335 MDS/AML cases were diagnosed posttransplant (3.7%). Variables associated with an increased risk for AML or MDS in multivariate analyses were: (1) conditioning with total body radiation versus chemotherapy alone for HL (HR = 4.0; 95% confidence interval [1.4, 11.6]) and NHL (HR = 2.5 [1.1, 2.5]); (2) ≥3 versus 1 line of chemotherapy for NHL (HR = 1.9 [1.3, 2.8]); and (3) subjects with NHL transplanted in 2005–2010 versus 1995–1999 (HR = 2.1 [1.5, 3.1]). Using Surveillance, Epidemiology and End Results (SEER) data, we found risks for AML/MDS in HL, NHL and PCM to be 5–10 times the background rate. In contrast, relative risks were 10–50 for AML and approximately 100 for MDS in the autotransplant cohort. Conclusions: There are substantial risks of AML and MDS after autotransplants for HL, NHL and PCM.

AB - Background: Exposures to DNA-damaging drugs and ionizing radiations increase risks of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Methods: 9028 recipients of hematopoietic cell autotransplants (1995–2010) for Hodgkin lymphoma (HL; n = 916), non-Hodgkin lymphoma (NHL; n = 3546) and plasma cell myeloma (PCM; n = 4566), reported to the CIBMTR, were analyzed for risk of subsequent AML or MDS. Results: 335 MDS/AML cases were diagnosed posttransplant (3.7%). Variables associated with an increased risk for AML or MDS in multivariate analyses were: (1) conditioning with total body radiation versus chemotherapy alone for HL (HR = 4.0; 95% confidence interval [1.4, 11.6]) and NHL (HR = 2.5 [1.1, 2.5]); (2) ≥3 versus 1 line of chemotherapy for NHL (HR = 1.9 [1.3, 2.8]); and (3) subjects with NHL transplanted in 2005–2010 versus 1995–1999 (HR = 2.1 [1.5, 3.1]). Using Surveillance, Epidemiology and End Results (SEER) data, we found risks for AML/MDS in HL, NHL and PCM to be 5–10 times the background rate. In contrast, relative risks were 10–50 for AML and approximately 100 for MDS in the autotransplant cohort. Conclusions: There are substantial risks of AML and MDS after autotransplants for HL, NHL and PCM.

KW - AML

KW - Autotransplant

KW - CIBMTR

KW - MDS

KW - New cancers

KW - SEER

KW - Therapy-related

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UR - http://www.scopus.com/inward/citedby.url?scp=85050340275&partnerID=8YFLogxK

U2 - 10.1016/j.leukres.2018.07.016

DO - 10.1016/j.leukres.2018.07.016

M3 - Article

C2 - 30055822

AN - SCOPUS:85050340275

SN - 0145-2126

VL - 74

SP - 130

EP - 136

JO - Leukemia Research

JF - Leukemia Research

ER -

Risk of acute myeloid leukemia and myelodysplastic syndrome after autotransplants for lymphomas and plasma cell myeloma

Abstract

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