Risk factors associated with death or neurological deterioration among patients with Gram-negative postneurosurgical meningitis

A. Neuberger, B. Shofty, B. Bishop, M. E. Naffaa, T. Binawi, T. Babich, Z. H. Rappaport, M. Zaaroor, G. Sviri, D. Yahav, M. Paul

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

In a retrospective cohort of 115 patients with Gram-negative postneurosurgical meningitis, factors associated with 30-day mortality or neurological deterioration on multivariate analysis included days from admission to meningitis (OR 1.05 per day, 95% CI 1.02–1.09), decreased level of consciousness (OR 2.69, 95% CI 0.99–7.31), blood glucose level >180 mg/dL (OR 3.70, 95% CI 1.27–10.77), higher creatinine level (OR 4.07 per 1 mg/dL, 95% CI 1.50–11.08), and cerebrospinal fluid glucose <50 mg/dL (OR 5.02, 95% CI 1.71–14.77) at diagnosis. A predictive score triaged patients into three groups with low (4/44, 9.1%), intermediate (16/38, 42.1%) and high (22/33, 66.7%) unfavourable outcome rates. Validation on a different group of 36 patients with Gram-negative postneurosurgical meningitis was acceptable.

Original languageEnglish (US)
Pages (from-to)573.e1-573.e4
JournalClinical Microbiology and Infection
Volume22
Issue number6
DOIs
StatePublished - Jun 1 2016

Keywords

  • Gram-negative
  • meningitis
  • neurosurgery
  • outcome
  • postneurosurgical
  • prognosis
  • prognostic factors
  • risk factors

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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