Ringed Sideroblasts in Primary Myelodysplasia: Leukemic Propensity and Prognostic Factors

Louis Vandermolen, Lawrence Rice, Mary Ann Rose, Edward C. Lynch

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Among 123 patients with ringed sideroblasts on bone marrow aspirates, 85 had acquired ringed sideroblasts with primary myelodysplasia. The patients were placed in categories modified from the French-American-British classification based on percentages of ringed sideroblasts and myeloblasts in the initial bone marrow. Overall, 48% (41/85) of patients with myelodysplasia developed acute leukemia. Primary acquired sideroblastic anemia was the most favorable category with longer survival and 13.8% (4/29) leukemic conversions. Variables correlating with leukemic transformation included male sex, thrombocytopenia, neutropenia, and pseudo-Pelger-Huet neutrophils. Only two variables had independent predictive value by multivariate regression analysis: a high percentage of myeloblasts and a low percentage of ringed sideroblasts. Numerous ringed sideroblasts strongly predicts a more favorable course in myelodysplastic patients.

Original languageEnglish (US)
Pages (from-to)653-656
Number of pages4
JournalArchives of Internal Medicine
Volume148
Issue number3
DOIs
StatePublished - Mar 1988

ASJC Scopus subject areas

  • Internal Medicine

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