Ringed Sideroblasts in Primary Myelodysplasia: Leukemic Propensity and Prognostic Factors

Louis Vandermolen, Lawrence Rice, Mary Ann Rose, Edward C. Lynch

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Among 123 patients with ringed sideroblasts on bone marrow aspirates, 85 had acquired ringed sideroblasts with primary myelodysplasia. The patients were placed in categories modified from the French-American-British classification based on percentages of ringed sideroblasts and myeloblasts in the initial bone marrow. Overall, 48% (41/85) of patients with myelodysplasia developed acute leukemia. Primary acquired sideroblastic anemia was the most favorable category with longer survival and 13.8% (4/29) leukemic conversions. Variables correlating with leukemic transformation included male sex, thrombocytopenia, neutropenia, and pseudo-Pelger-Huet neutrophils. Only two variables had independent predictive value by multivariate regression analysis: a high percentage of myeloblasts and a low percentage of ringed sideroblasts. Numerous ringed sideroblasts strongly predicts a more favorable course in myelodysplastic patients.

Original languageEnglish (US)
Pages (from-to)653-656
Number of pages4
JournalArchives of Internal Medicine
Issue number3
StatePublished - Mar 1988

ASJC Scopus subject areas

  • Internal Medicine


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