Ribosome-lamella complexes in a case of transitional cell carcinoma involving the prostate

Yuji Ohtsuki, Bruce Mackay, Jae Y. Ro, Alberto G. Ayala

Research output: Contribution to journalArticle

Abstract

We report ribosome-lamella complexes (RLC) in cancer cells of transitional cell carcinoma (TCC) of the prostate in a 52-year-old Caucasian man. Histopathologically, cancer cells were proliferated in various-sized nests, mostly associated with central necrosis. Some invaded into the surrounding normal glandular space and the stroma, with occasional lymphatic invasion. Fine structural study of cancer cells revealed that cross-sectioned RLC as well as densely aggregated ribosomes were detected in their cytoplasm, situated close to, but not directly connected with, dilated rough endoplasmic reticulum. These were composed of a concentric alternative arrangement of both lamellae and ribosomes. In the central and surrounding parts of the RLC, ribosomes were observed, revealing a smooth transition to the ribosomal component of RLC in size and shape. The presence of both RLC and dense aggregation of ribosomes close to the rough endoplasmic reticulum suggests that their functions might be related to specific or aberrant protein synthesis under unknown conditions. Although RLC have been often reported in hematopoietic malignancies, their occurrence in the malignant epithelial component has been only reported in a case of pulmonary adenocarcinoma. This is the first report of RLC in TCC in the literature.

Original languageEnglish (US)
Pages (from-to)222-225
Number of pages4
JournalMedical Molecular Morphology
Volume31
Issue number4
DOIs
StatePublished - 1998

Keywords

  • Prostate
  • Ribosome-lamella complexes
  • Transitional cell carcinoma

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Molecular Biology

Fingerprint Dive into the research topics of 'Ribosome-lamella complexes in a case of transitional cell carcinoma involving the prostate'. Together they form a unique fingerprint.

Cite this