Abstract

In vertebrate cells, the Golgi apparatus is located in close proximity to the centriole. The architecture of the Golgi/centriole complex depends on a multitude of factors, including the actin filament cytoskeleton. In turn, both the Golgi and centriole act as the actin nucleation centers. Actin organization and polymerization also depend on the small GTPase RhoA pathway. In this chapter, we summarize the most current knowledge on how the genetic, magnetic, or pharmacologic interference with RhoA pathway and actin cytoskeleton directly or indirectly affects architecture, structure, and function of the Golgi/centriole complex.

Original languageEnglish (US)
Title of host publicationResults and Problems in Cell Differentiation
PublisherSpringer-Verlag
Pages81-93
Number of pages13
DOIs
StatePublished - 2019

Publication series

NameResults and Problems in Cell Differentiation
Volume67
ISSN (Print)0080-1844
ISSN (Electronic)1861-0412

Keywords

  • Actin Cytoskeleton/metabolism
  • Actins/metabolism
  • Centrioles/metabolism
  • Golgi Apparatus/metabolism
  • rhoA GTP-Binding Protein/metabolism

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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