Abstract

Mucormycosis is a rare and often fatal opportunistic angioinvasive infection seen mostly in immunocompromised patients, such as those with diabetes mellitus, cancer, or renal failure. Ophthalmic manifestations of orbital mucormycosis include ocular pain, periocular oedema, visual loss, ophthalmoplegia, proptosis, and ptosis. Although therapy for orbital mucormycosis consists of maximally tolerated doses of antifungal agents (e.g., amphotericin B) and extensive surgical debridement, treatment remains ineffective in up to 20% of cases. We describe two patients with rhino-orbitalmucormycosis who were successfully treated with posaconazole in conjunction with intravenous (IV) amphotericin B and sinus surgical debridement. These cases highlight several unusual early manifestations of orbital mucormycosis, including disc oedema and amaurosis fugax, as well as the applicability of a new extended-spectrum antifungal agent in management of orbital zygomycosis.

Original languageEnglish (US)
Pages (from-to)198-203
Number of pages6
JournalNeuro-Ophthalmology
Volume37
Issue number5
DOIs
StatePublished - Oct 2013

Keywords

  • Disc oedema
  • Mucormycosis
  • Orbital apex syndrome
  • Posaconazole
  • Rhino-orbital

ASJC Scopus subject areas

  • Ophthalmology
  • Clinical Neurology

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