Review article: From gastrin to gastro-oesophageal reflux disease - A century of acid suppression

P. Malfertheiner, R. Fass, E. M M Quigley, I. M. Modlin, J. R. Malagelada, S. F. Moss, G. Holtmann, K. L. Goh, P. Katelaris, V. Stanghellini, N. J. Talley, G. N. Tytgat, N. A. Wright

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


To commemorate Edkins' discovery of gastrin in 1905, we review a century of progress in the physiology and pathobiology of gastrin and acid secretion especially as it pertains to clinical aspects of gastro-oesophageal reflux disease. Although initially ignored, Edkins' observations eventually led to the enthusiastic investigation of gastrin and acid regulation in peptic ulcer disease, culminating in important therapeutic advances in the management of acid peptic disease. Following the improved understanding of gastric secretory physiology, and the development of acid suppressants with increasing efficacy, the use of surgical intervention for peptic ulcer disease was almost eliminated. Surgery became obsolete with the discovery of Helicobacter pylori. Three other advances are also influencing modern practice: the gastrotoxicity of aspirin and non-steroidal anti-inflammatory drugs is now increasingly appreciated, the role of endoscopy in the diagnosis and therapy of upper gastrointestinal bleeding, and the use of intravenous acid-suppressive agents. The major issue for the future resides within the epidemic of gastro-oesophageal reflux disease. How to diagnose, categorize and treat this condition and how to identify and prevent neoplasia, are the challenges of the new century.

Original languageEnglish (US)
Pages (from-to)683-690
Number of pages8
JournalAlimentary Pharmacology and Therapeutics
Issue number6
StatePublished - Mar 2006

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology
  • Pharmacology (medical)


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