Reversal of the immunosuppressive tumor microenvironment by nanoparticle-based activation of immune-associated cells

Fei long Qi, Mei fang Wang, Bo zhao Li, Ze fang Lu, Guang jun Nie, Su ping Li

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Immunotherapy that activates the host immune system to reverse immunosuppression has emerged as a new generation of cancer treatment in both preclinical studies and clinical trials. Although immunotherapy has shown significant achievements in the treatment of various cancers, it faces challenges that limit its further evolution such as poor permeation and modest responsiveness. The development of nanoparticle drug delivery system has provided an opportunity to overcome these drawbacks and to achieve optimized immunotherapy. Based on the research of our group, we here introduce the new strategies being employed using nanoscale intelligent drug delivery systems to enhance the effects of cancer immunotherapy. We also provide a perspective on the further possible application of nanoparticles in more effective antitumor immunotherapy.

Original languageEnglish (US)
Pages (from-to)895-901
Number of pages7
JournalActa Pharmacologica Sinica
Volume41
Issue number7
DOIs
StatePublished - Jul 1 2020

Keywords

  • cancer immunotherapy
  • dendritic cells
  • immune checkpoint inhibitors
  • nanoparticles
  • natural killer cells
  • tumor microenvironment
  • tumor vaccine

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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