TY - JOUR
T1 - Reversal of left-right asymmetry
T2 - A situs inversus mutation
AU - Yokoyama, Takahiko
AU - Copeland, Neal G.
AU - Jenkins, Nancy A.
AU - Montgomery, Charles A.
AU - Elder, Frederick F.B.
AU - Overbeek, Paul A.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1993
Y1 - 1993
N2 - A recessive mutation was identified in a family of transgenic mice that resulted in a reversal of left-right polarity (situs inversus) in 100 percent of the homozygous transgenic mice tested. Sequences that flanked the transgenic integration site were cloned and mapped to mouse chromosome 4, between the Tsha and Hxb loci. During early embryonic development, the direction of postimplantation turning, one of the earliest manifestations of left-right asymmetry, was reversed in homozygous transgenic embryos. This insertional mutation identifies a gene that controls embryonic turning and visceral left-right polarity.
AB - A recessive mutation was identified in a family of transgenic mice that resulted in a reversal of left-right polarity (situs inversus) in 100 percent of the homozygous transgenic mice tested. Sequences that flanked the transgenic integration site were cloned and mapped to mouse chromosome 4, between the Tsha and Hxb loci. During early embryonic development, the direction of postimplantation turning, one of the earliest manifestations of left-right asymmetry, was reversed in homozygous transgenic embryos. This insertional mutation identifies a gene that controls embryonic turning and visceral left-right polarity.
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U2 - 10.1126/science.8480178
DO - 10.1126/science.8480178
M3 - Article
C2 - 8480178
AN - SCOPUS:0027158027
VL - 260
SP - 679
EP - 682
JO - Science (New York, N.Y.)
JF - Science (New York, N.Y.)
SN - 0036-8075
IS - 5108
ER -