Reversal of left-right asymmetry: A situs inversus mutation

Takahiko Yokoyama, Neal G. Copeland, Nancy A. Jenkins, Charles A. Montgomery, Frederick F.B. Elder, Paul A. Overbeek

Research output: Contribution to journalArticle

351 Scopus citations

Abstract

A recessive mutation was identified in a family of transgenic mice that resulted in a reversal of left-right polarity (situs inversus) in 100 percent of the homozygous transgenic mice tested. Sequences that flanked the transgenic integration site were cloned and mapped to mouse chromosome 4, between the Tsha and Hxb loci. During early embryonic development, the direction of postimplantation turning, one of the earliest manifestations of left-right asymmetry, was reversed in homozygous transgenic embryos. This insertional mutation identifies a gene that controls embryonic turning and visceral left-right polarity.

Original languageEnglish (US)
Pages (from-to)679-682
Number of pages4
JournalScience
Volume260
Issue number5108
DOIs
StatePublished - 1993

ASJC Scopus subject areas

  • General

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