Retroviral DNA content of the mouse genome.

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Mice, like many other vertebrate species, carry multiple copies of retrovirus-related sequences as part of their normal genetic complement. These endogenous retroviral DNA sequences are, in general, structurally and functionally similar to proviruses formed via exogenous virus infection. They behave as relatively stable genetic entities, are transmitted in a normal mendelian manner, and can be expressed by normal cellular mechanisms. Chromosome mapping studies have shown that these virus-related sequences are dispersed throughout the mouse genome, in most cases were acquired after speciation but before inbreeding, and occasionally cause mutations as a result of integrating within the mouse genome.

Original languageEnglish (US)
Pages (from-to)109-122
Number of pages14
JournalBirth defects original article series
Volume23
Issue number3
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Developmental Biology
  • Genetics(clinical)

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