Retroperitoneal Sarcomas: An Update on the Diagnostic Pathology Approach

Joon Hyuk Choi, Jae Y. Ro

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


Retroperitoneal sarcomas are a heterogenous group of rare tumors arising in the retroperitoneum. Retroperitoneal sarcomas comprise approximately 10% of all soft tissue sarcomas. Though any soft tissue sarcoma histologic types may arise in the retroperitoneal space, liposarcoma (especially well-differentiated and dedifferentiated types) and leiomyosarcoma do so most commonly. Retroperitoneal sarcomas are diagnostically challenging, owing to their diversity and morphological overlap with other tumors arising in the retroperitoneum. An accurate diagnosis is necessary for correct management and prognostication. Herein, we provide an update on the diagnostic approach to retroperitoneal sarcomas and review their key histologic findings and differential diagnoses.

Original languageEnglish (US)
Article number642
Issue number9
StatePublished - Aug 27 2020


  • Leiomyosarcoma
  • Liposarcoma
  • Pathology
  • Retroperitoneal space
  • Sarcoma

ASJC Scopus subject areas

  • Clinical Biochemistry


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