Retroperitoneal sarcoma presenting as acute renal failure, secondary to bilateral renal artery invasion

Amit Gupta, Omar Pacha, Rony Skaria, Tam Huynh, Luan Truong, Abdul Abdellatif

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Retroperitoneal sarcoma is a rare tumor accounting for 10 - 15% of all soft tissue malignancies with an incidence of 2.5 per million. Of those, liposarcoma is the most common type of retroperitoneal sarcoma accounting for 41% of cases. It usually presents late with vague symptoms such as abdominal discomfort or palpable mass. Vascular invasion is seen in 18% of retroperitoneal sarcomas but acute renal failure secondary to bilateral renal artery invasion/stenosis by these tumors has never been described yet. In this report, we describe the first case, to our knowledge, in the medical literature and discuss epidemiology, diagnosis, and management. Treatment is primarily surgical and the ability to completely resect the tumor is the most important predictor of survival. Active clinical trials are currently testing the use of adjunct chemotherapy and radiotherapy to improve morbidity and mortality by initiation of angiotensinogen converting enzyme inhibitors (ACEI). Retroperitoneal liposarcomas account for 0.15% of all malignancies in humans [2]. Symptoms manifest with the effect of the mass on adjacent organs or nerves that may precipitate neurological symptoms in extremities. However vascular invasion is rare (18%) and invasion of both artery and vein (2.88%) even more so [3]. To our knowledge, this is the first report of a retroperitoneal liposarcoma causing bilateral constriction of the renal arteries leading to anuric-acute kidney failure.

Original languageEnglish (US)
Pages (from-to)164-168
Number of pages5
JournalClinical Nephrology
Issue number2
StatePublished - Aug 1 2012


  • Acute renal failure
  • Doppler ultrasonagraphy
  • Renal artery stenosis
  • Sarcoma
  • Time of flight mri

ASJC Scopus subject areas

  • Nephrology


Dive into the research topics of 'Retroperitoneal sarcoma presenting as acute renal failure, secondary to bilateral renal artery invasion'. Together they form a unique fingerprint.

Cite this