Retrogeniculate Lesion of the Visual Pathways: Retinal Optical Coherence Tomography Angiography Shows Evidence of Transsynaptic Retrograde Degeneration

Francesco Pellegrini; Emanuela Interlandi; Francesco Pichi; Andrew G. Lee

doi:10.1080/01658107.2019.1617748

Retrogeniculate Lesion of the Visual Pathways: Retinal Optical Coherence Tomography Angiography Shows Evidence of Transsynaptic Retrograde Degeneration

Francesco Pellegrini, Emanuela Interlandi, Francesco Pichi, Andrew G. Lee

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Transsynaptic retrograde degeneration (TSRD) of the visual pathways is the loss of retinal ganglion cells occurring upstream from a posterior visual pathway lesion. We present a case of a 54-year-old woman with an epidermoid cyst at the right temporo-occipital junction, in whom retinal optical coherence tomography angiography showed a reduction of the superficial retinal capillary density consistent with TSRD. While this reduction has been described in chronic optic neuropathies and pregeniculate lesions, to our knowledge, this is the first case report showing how a reduction in the superficial retinal capillary density occurs also for a postgeniculate lesion.

Original language	English (US)
Pages (from-to)	114-117
Number of pages	4
Journal	Neuro-Ophthalmology
Volume	44
Issue number	2
DOIs	https://doi.org/10.1080/01658107.2019.1617748
State	E-pub ahead of print - Jul 12 2020

Keywords

Optical coherence tomography angiography
superficial capillary plexus
transsynaptic retrograde degeneration

ASJC Scopus subject areas

Ophthalmology
Clinical Neurology

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10.1080/01658107.2019.1617748

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title = "Retrogeniculate Lesion of the Visual Pathways: Retinal Optical Coherence Tomography Angiography Shows Evidence of Transsynaptic Retrograde Degeneration",

abstract = "Transsynaptic retrograde degeneration (TSRD) of the visual pathways is the loss of retinal ganglion cells occurring upstream from a posterior visual pathway lesion. We present a case of a 54-year-old woman with an epidermoid cyst at the right temporo-occipital junction, in whom retinal optical coherence tomography angiography showed a reduction of the superficial retinal capillary density consistent with TSRD. While this reduction has been described in chronic optic neuropathies and pregeniculate lesions, to our knowledge, this is the first case report showing how a reduction in the superficial retinal capillary density occurs also for a postgeniculate lesion.",

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AU - Pichi, Francesco

AU - Lee, Andrew G.

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AB - Transsynaptic retrograde degeneration (TSRD) of the visual pathways is the loss of retinal ganglion cells occurring upstream from a posterior visual pathway lesion. We present a case of a 54-year-old woman with an epidermoid cyst at the right temporo-occipital junction, in whom retinal optical coherence tomography angiography showed a reduction of the superficial retinal capillary density consistent with TSRD. While this reduction has been described in chronic optic neuropathies and pregeniculate lesions, to our knowledge, this is the first case report showing how a reduction in the superficial retinal capillary density occurs also for a postgeniculate lesion.

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KW - superficial capillary plexus

KW - transsynaptic retrograde degeneration

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Retrogeniculate Lesion of the Visual Pathways: Retinal Optical Coherence Tomography Angiography Shows Evidence of Transsynaptic Retrograde Degeneration

Abstract

Keywords

ASJC Scopus subject areas

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