RETINAL VASCULAR BED AREA IN EYES WITH RETINAL VEIN OCCLUSION ON ULTRA-WIDEFIELD FLUORESCEIN ANGIOGRAPHY: WAVE Study

Wenying Fan, Alan Fleming, Jano Van Hemert, Charles C. Wykoff, David M. Brown, Gavin Robertson, Kang Wang, Khalil Ghasemi Falavarjani, Srinivas R. Sadda, Michael Ip

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose:To compute retinal vascular bed area (RVBA) in square millimeters on distortion corrected ultra-widefield fluorescein angiography images in eyes with retinal vein occlusion (RVO).Methods:Prospective observational study. The peripheral distortion of baseline ultra-widefield fluorescein angiography (Optos 200Tx) images of 30 patients with RVO from the WAVE study (NCT01710839) and 13 control eyes of normal subjects was corrected using the stereographic projection method to compute RVBA in square millimeters.Results:In comparison with age- and sex-matched normal control eyes, eyes with RVO had a decreased global RVBA for the entire retina (50.5 ± 20.4 mm2 vs. 62.6 ± 12.2 mm2, P = 0.023). Eyes with RVO and the unaffected fellow eye had a similar RVBA globally (50.5 ± 20.4 mm2 vs. 46.2 ± 18.9 mm2, P = 0.523). The RVBA was observed to negatively correlate with nonperfusion area (R = -0.47, P = 0.009). However, RVBA was not related to the severity of macular edema (P > 0.05).Conclusion:Eyes with RVO have a similar RVBA to the unaffected fellow eyes but with a reduction when compared with normal control eyes. Retinal vascular bed area appears to be a surrogate biomarker of retinal ischemia on ultra-widefield fluorescein angiography but not the extent of macular edema.

Original languageEnglish (US)
Pages (from-to)1883-1888
Number of pages6
JournalRetina
Volume42
Issue number10
DOIs
StatePublished - Oct 1 2022

Keywords

  • retinal vascular bed area
  • retinal vein occlusion
  • ultra-widefield

ASJC Scopus subject areas

  • Ophthalmology

Fingerprint

Dive into the research topics of 'RETINAL VASCULAR BED AREA IN EYES WITH RETINAL VEIN OCCLUSION ON ULTRA-WIDEFIELD FLUORESCEIN ANGIOGRAPHY: WAVE Study'. Together they form a unique fingerprint.

Cite this