Restless abdomen: A spectrum or a phenotype variant of restless legs syndrome?

Xi Xi Wang, Xiao Ying Zhu, Zan Wang, Jian Wei Dong, William G. Ondo, Yun Cheng Wu

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Background: With the growing awareness of restless legs syndrome (RLS), sensory disorders similar to RLS but initially confined to the arms, abdomen, and perineum have been reported. One of them is restless abdomen, which refers to a restless sensation in abdomen. Our study is designed to evaluate the clinical phenotype of restless abdomen and investigate its relationship with RLS. Methods: We enrolled 10 patients with restless abdomen according to RLS diagnostic criteria, excluding the requiring of leg involvement. Laboratory examinations were performed to exclude mimics and notable comorbidities. Results: All 10 patients had RLS like symptoms in the abdomen and otherwise satisfied all other RLS diagnostic criteria, and responded to dopaminergic therapy. Conclusions: Neurologists and gastroenterologists should be aware that RLS-related restlessness can occur in extra-leg anatomy in the absence of episodes of worsening or augmentation of restlessness.

Original languageEnglish (US)
Article number298
JournalBMC neurology
Issue number1
StatePublished - Aug 12 2020


  • Dopaminergic therapy
  • Insomnia
  • Restless abdomen
  • Restless legs syndrome

ASJC Scopus subject areas

  • Clinical Neurology


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