Resting diastolic function and left ventricular mass are related to exercise capacity in hypertensive men but not in women

Ali G. Gharavi, Joseph A. Diamond, Adam Y. Goldman, Neil L. Coplan, Jeffrey S. Jhang, Marilyn Steinmetz, Rochelle Goldsmith, Robert A. Phillips

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

We evaluated the impact of diastolic function and gender on exercise capacity in sedentary,-untreated hypertensive subjects (34 men, 23 women) using echocardiography and a bicycle ergometry with measurement of oxygen consumption (VO2). In men, peak (A) mitral inflow velocity and left ventricular (LV) mass were inversely related to peak VO2 (r = -0.64) and maximal workload (r = -0.57) and were the sole independent determinants of exercise capacity. In women, there was no relationship between any echocardiographic measure and exercise capacity. Thus, LV mass and Doppler- determined diastolic function predict maximal VO2 in hypertensive men but not in women. This finding may be related to gender differences in the contribution of diastolic filling to exercise capacity or may reflect limitations of resting Doppler echocardiography to predict exercise diastolic filling in hypertensive women.

Original languageEnglish (US)
Pages (from-to)1252-1257
Number of pages6
JournalAmerican Journal of Hypertension
Volume11
Issue number10 I
DOIs
StatePublished - Oct 1998

Keywords

  • Diastolic function
  • Echocardiography
  • Exercise capacity
  • Gender
  • Men
  • Women

ASJC Scopus subject areas

  • Internal Medicine

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