Responses and receptive fields of amacrine cells and ganglion cells in the salamander retina

Ai Jun Zhang; Samuel M. Wu

doi:10.1016/j.visres.2010.01.009

Responses and receptive fields of amacrine cells and ganglion cells in the salamander retina

Ai Jun Zhang, Samuel M. Wu

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Retinal amacrine cells (ACs) and ganglion cells (GCs) have been shown to display large morphological diversity, and here we show that four types of ACs and three types of GCs exhibit physiologically-distinguishable properties. They are the sustained ON ACs; sustained OFF ACs; transient ON-OFF ACs; transient ON-OFF ACs with wide receptive fields; sustained ON-center/OFF-surround GCs; sustained OFF-center/ON-surround GCs and transient ON-OFF GCs. By comparing response waveforms, receptive fields and relative rod/cone inputs of ACs and GCs with the corresponding parameters of various types of the presynaptic bipolar cells (BCs), we analyze how different types of BCs mediate synaptic inputs to various ACs and GCs. Although more types of third-order retinal neurons may be identified by more refined classification criteria, our observations suggest that many morphologically-distinct ACs and GCs share very similar physiological responses.

Original language	English (US)
Pages (from-to)	614-622
Number of pages	9
Journal	Vision Research
Volume	50
Issue number	6
DOIs	https://doi.org/10.1016/j.visres.2010.01.009
State	Published - Mar 17 2010

Keywords

Center-surround antagonistic receptive fields
Dendritic fields
Electrical coupling
Relative rod/cone inputs
Response waveforms
Spatial information processing

ASJC Scopus subject areas

Ophthalmology
Sensory Systems

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10.1016/j.visres.2010.01.009

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title = "Responses and receptive fields of amacrine cells and ganglion cells in the salamander retina",

abstract = "Retinal amacrine cells (ACs) and ganglion cells (GCs) have been shown to display large morphological diversity, and here we show that four types of ACs and three types of GCs exhibit physiologically-distinguishable properties. They are the sustained ON ACs; sustained OFF ACs; transient ON-OFF ACs; transient ON-OFF ACs with wide receptive fields; sustained ON-center/OFF-surround GCs; sustained OFF-center/ON-surround GCs and transient ON-OFF GCs. By comparing response waveforms, receptive fields and relative rod/cone inputs of ACs and GCs with the corresponding parameters of various types of the presynaptic bipolar cells (BCs), we analyze how different types of BCs mediate synaptic inputs to various ACs and GCs. Although more types of third-order retinal neurons may be identified by more refined classification criteria, our observations suggest that many morphologically-distinct ACs and GCs share very similar physiological responses.",

keywords = "Center-surround antagonistic receptive fields, Dendritic fields, Electrical coupling, Relative rod/cone inputs, Response waveforms, Spatial information processing",

author = "Zhang, {Ai Jun} and Wu, {Samuel M.}",

note = "Funding Information: We thank Andrew Barrow and Roy Jacoby for critically reading this manuscript. This work was supported by grants from NIH ( EY 04446 ), NIH Vision Core ( EY 02520 ), the Retina Research Foundation (Houston), and the Research to Prevent Blindness, Inc.",

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AU - Wu, Samuel M.

N1 - Funding Information: We thank Andrew Barrow and Roy Jacoby for critically reading this manuscript. This work was supported by grants from NIH ( EY 04446 ), NIH Vision Core ( EY 02520 ), the Retina Research Foundation (Houston), and the Research to Prevent Blindness, Inc.

PY - 2010/3/17

Y1 - 2010/3/17

N2 - Retinal amacrine cells (ACs) and ganglion cells (GCs) have been shown to display large morphological diversity, and here we show that four types of ACs and three types of GCs exhibit physiologically-distinguishable properties. They are the sustained ON ACs; sustained OFF ACs; transient ON-OFF ACs; transient ON-OFF ACs with wide receptive fields; sustained ON-center/OFF-surround GCs; sustained OFF-center/ON-surround GCs and transient ON-OFF GCs. By comparing response waveforms, receptive fields and relative rod/cone inputs of ACs and GCs with the corresponding parameters of various types of the presynaptic bipolar cells (BCs), we analyze how different types of BCs mediate synaptic inputs to various ACs and GCs. Although more types of third-order retinal neurons may be identified by more refined classification criteria, our observations suggest that many morphologically-distinct ACs and GCs share very similar physiological responses.

AB - Retinal amacrine cells (ACs) and ganglion cells (GCs) have been shown to display large morphological diversity, and here we show that four types of ACs and three types of GCs exhibit physiologically-distinguishable properties. They are the sustained ON ACs; sustained OFF ACs; transient ON-OFF ACs; transient ON-OFF ACs with wide receptive fields; sustained ON-center/OFF-surround GCs; sustained OFF-center/ON-surround GCs and transient ON-OFF GCs. By comparing response waveforms, receptive fields and relative rod/cone inputs of ACs and GCs with the corresponding parameters of various types of the presynaptic bipolar cells (BCs), we analyze how different types of BCs mediate synaptic inputs to various ACs and GCs. Although more types of third-order retinal neurons may be identified by more refined classification criteria, our observations suggest that many morphologically-distinct ACs and GCs share very similar physiological responses.

KW - Center-surround antagonistic receptive fields

KW - Dendritic fields

KW - Electrical coupling

KW - Relative rod/cone inputs

KW - Response waveforms

KW - Spatial information processing

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Responses and receptive fields of amacrine cells and ganglion cells in the salamander retina

Abstract

Keywords

ASJC Scopus subject areas

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