Response assessment in paediatric low-grade glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group

Jason Fangusaro; Olaf Witt; Pablo Hernáiz Driever; Asim K. Bag; Peter de Blank; Nadja Kadom; Lindsay Kilburn; Robert M. Lober; Nathan J. Robison; Michael J. Fisher; Roger J. Packer; Tina Young Poussaint; Ludmila Papusha; Shivaram Avula; Alba A. Brandes; Eric Bouffet; Daniel Bowers; Anton Artemov; Murali Chintagumpala; David Zurakowski; Martin van den Bent; Brigitte Bison; Kristen W. Yeom; Walter Taal; Katherine E. Warren

doi:10.1016/S1470-2045(20)30064-4

Response assessment in paediatric low-grade glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group

Jason Fangusaro, Olaf Witt, Pablo Hernáiz Driever, Asim K. Bag, Peter de Blank, Nadja Kadom, Lindsay Kilburn, Robert M. Lober, Nathan J. Robison, Michael J. Fisher, Roger J. Packer, Tina Young Poussaint, Ludmila Papusha, Shivaram Avula, Alba A. Brandes, Eric Bouffet, Daniel Bowers, Anton Artemov, Murali Chintagumpala, David ZurakowskiMartin van den Bent, Brigitte Bison, Kristen W. Yeom, Walter Taal, Katherine E. Warren

Houston Methodist

Research output: Contribution to journal › Review article › peer-review

161 Scopus citations

Abstract

Paediatric low-grade gliomas (also known as pLGG) are the most common type of CNS tumours in children. In general, paediatric low-grade gliomas show clinical and biological features that are distinct from adult low-grade gliomas, and the developing paediatric brain is more susceptible to toxic late effects of the tumour and its treatment. Therefore, response assessment in children requires additional considerations compared with the adult Response Assessment in Neuro-Oncology criteria. There are no standardised response criteria in paediatric clinical trials, which makes it more difficult to compare responses across studies. The Response Assessment in Pediatric Neuro-Oncology working group, consisting of an international panel of paediatric and adult neuro-oncologists, clinicians, radiologists, radiation oncologists, and neurosurgeons, was established to address issues and unique challenges in assessing response in children with CNS tumours. We established a subcommittee to develop consensus recommendations for response assessment in paediatric low-grade gliomas. Final recommendations were based on literature review, current practice, and expert opinion of working group members. Consensus recommendations include imaging response assessments, with additional guidelines for visual functional outcomes in patients with optic pathway tumours. As with previous consensus recommendations, these recommendations will need to be validated in prospective clinical trials.

Original language	English (US)
Pages (from-to)	e305-e316
Journal	The Lancet Oncology
Volume	21
Issue number	6
DOIs	https://doi.org/10.1016/S1470-2045(20)30064-4
State	Published - Jun 2020

Keywords

Age of Onset
Central Nervous System Neoplasms/diagnostic imaging
Child
Consensus
Endpoint Determination/standards
Female
Glioma/diagnostic imaging
Humans
Magnetic Resonance Imaging/standards
Male
Neoplasm Grading
Neuroimaging/standards
Perfusion Imaging/standards
Positron-Emission Tomography/standards
Predictive Value of Tests
Time Factors
Treatment Outcome
Tumor Burden

ASJC Scopus subject areas

Oncology

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10.1016/S1470-2045(20)30064-4

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Fangusaro, J., Witt, O., Hernáiz Driever, P., Bag, A. K., de Blank, P., Kadom, N., Kilburn, L., Lober, R. M., Robison, N. J., Fisher, M. J., Packer, R. J., Young Poussaint, T., Papusha, L., Avula, S., Brandes, A. A., Bouffet, E., Bowers, D., Artemov, A., Chintagumpala, M., ... Warren, K. E. (2020). Response assessment in paediatric low-grade glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group. The Lancet Oncology, 21(6), e305-e316. https://doi.org/10.1016/S1470-2045(20)30064-4

Fangusaro, J, Witt, O, Hernáiz Driever, P, Bag, AK, de Blank, P, Kadom, N, Kilburn, L, Lober, RM, Robison, NJ, Fisher, MJ, Packer, RJ, Young Poussaint, T, Papusha, L, Avula, S, Brandes, AA, Bouffet, E, Bowers, D, Artemov, A, Chintagumpala, M, Zurakowski, D, van den Bent, M, Bison, B, Yeom, KW, Taal, W & Warren, KE 2020, 'Response assessment in paediatric low-grade glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group', The Lancet Oncology, vol. 21, no. 6, pp. e305-e316. https://doi.org/10.1016/S1470-2045(20)30064-4

@article{9d89186003a04a589bfe845f73413999,

title = "Response assessment in paediatric low-grade glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group",

abstract = "Paediatric low-grade gliomas (also known as pLGG) are the most common type of CNS tumours in children. In general, paediatric low-grade gliomas show clinical and biological features that are distinct from adult low-grade gliomas, and the developing paediatric brain is more susceptible to toxic late effects of the tumour and its treatment. Therefore, response assessment in children requires additional considerations compared with the adult Response Assessment in Neuro-Oncology criteria. There are no standardised response criteria in paediatric clinical trials, which makes it more difficult to compare responses across studies. The Response Assessment in Pediatric Neuro-Oncology working group, consisting of an international panel of paediatric and adult neuro-oncologists, clinicians, radiologists, radiation oncologists, and neurosurgeons, was established to address issues and unique challenges in assessing response in children with CNS tumours. We established a subcommittee to develop consensus recommendations for response assessment in paediatric low-grade gliomas. Final recommendations were based on literature review, current practice, and expert opinion of working group members. Consensus recommendations include imaging response assessments, with additional guidelines for visual functional outcomes in patients with optic pathway tumours. As with previous consensus recommendations, these recommendations will need to be validated in prospective clinical trials.",

keywords = "Age of Onset, Central Nervous System Neoplasms/diagnostic imaging, Child, Consensus, Endpoint Determination/standards, Female, Glioma/diagnostic imaging, Humans, Magnetic Resonance Imaging/standards, Male, Neoplasm Grading, Neuroimaging/standards, Perfusion Imaging/standards, Positron-Emission Tomography/standards, Predictive Value of Tests, Time Factors, Treatment Outcome, Tumor Burden",

author = "Jason Fangusaro and Olaf Witt and \{Hern{\'a}iz Driever\}, Pablo and Bag, \{Asim K.\} and \{de Blank\}, Peter and Nadja Kadom and Lindsay Kilburn and Lober, \{Robert M.\} and Robison, \{Nathan J.\} and Fisher, \{Michael J.\} and Packer, \{Roger J.\} and \{Young Poussaint\}, Tina and Ludmila Papusha and Shivaram Avula and Brandes, \{Alba A.\} and Eric Bouffet and Daniel Bowers and Anton Artemov and Murali Chintagumpala and David Zurakowski and \{van den Bent\}, Martin and Brigitte Bison and Yeom, \{Kristen W.\} and Walter Taal and Warren, \{Katherine E.\}",

year = "2020",

month = jun,

doi = "10.1016/S1470-2045(20)30064-4",

language = "English (US)",

volume = "21",

pages = "e305--e316",

journal = "The Lancet Oncology",

issn = "1470-2045",

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number = "6",

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TY - JOUR

T1 - Response assessment in paediatric low-grade glioma

T2 - recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group

AU - Fangusaro, Jason

AU - Witt, Olaf

AU - Hernáiz Driever, Pablo

AU - Bag, Asim K.

AU - de Blank, Peter

AU - Kadom, Nadja

AU - Kilburn, Lindsay

AU - Lober, Robert M.

AU - Robison, Nathan J.

AU - Fisher, Michael J.

AU - Packer, Roger J.

AU - Young Poussaint, Tina

AU - Papusha, Ludmila

AU - Avula, Shivaram

AU - Brandes, Alba A.

AU - Bouffet, Eric

AU - Bowers, Daniel

AU - Artemov, Anton

AU - Chintagumpala, Murali

AU - Zurakowski, David

AU - van den Bent, Martin

AU - Bison, Brigitte

AU - Yeom, Kristen W.

AU - Taal, Walter

AU - Warren, Katherine E.

PY - 2020/6

Y1 - 2020/6

N2 - Paediatric low-grade gliomas (also known as pLGG) are the most common type of CNS tumours in children. In general, paediatric low-grade gliomas show clinical and biological features that are distinct from adult low-grade gliomas, and the developing paediatric brain is more susceptible to toxic late effects of the tumour and its treatment. Therefore, response assessment in children requires additional considerations compared with the adult Response Assessment in Neuro-Oncology criteria. There are no standardised response criteria in paediatric clinical trials, which makes it more difficult to compare responses across studies. The Response Assessment in Pediatric Neuro-Oncology working group, consisting of an international panel of paediatric and adult neuro-oncologists, clinicians, radiologists, radiation oncologists, and neurosurgeons, was established to address issues and unique challenges in assessing response in children with CNS tumours. We established a subcommittee to develop consensus recommendations for response assessment in paediatric low-grade gliomas. Final recommendations were based on literature review, current practice, and expert opinion of working group members. Consensus recommendations include imaging response assessments, with additional guidelines for visual functional outcomes in patients with optic pathway tumours. As with previous consensus recommendations, these recommendations will need to be validated in prospective clinical trials.

AB - Paediatric low-grade gliomas (also known as pLGG) are the most common type of CNS tumours in children. In general, paediatric low-grade gliomas show clinical and biological features that are distinct from adult low-grade gliomas, and the developing paediatric brain is more susceptible to toxic late effects of the tumour and its treatment. Therefore, response assessment in children requires additional considerations compared with the adult Response Assessment in Neuro-Oncology criteria. There are no standardised response criteria in paediatric clinical trials, which makes it more difficult to compare responses across studies. The Response Assessment in Pediatric Neuro-Oncology working group, consisting of an international panel of paediatric and adult neuro-oncologists, clinicians, radiologists, radiation oncologists, and neurosurgeons, was established to address issues and unique challenges in assessing response in children with CNS tumours. We established a subcommittee to develop consensus recommendations for response assessment in paediatric low-grade gliomas. Final recommendations were based on literature review, current practice, and expert opinion of working group members. Consensus recommendations include imaging response assessments, with additional guidelines for visual functional outcomes in patients with optic pathway tumours. As with previous consensus recommendations, these recommendations will need to be validated in prospective clinical trials.

KW - Age of Onset

KW - Central Nervous System Neoplasms/diagnostic imaging

KW - Child

KW - Consensus

KW - Endpoint Determination/standards

KW - Female

KW - Glioma/diagnostic imaging

KW - Humans

KW - Magnetic Resonance Imaging/standards

KW - Male

KW - Neoplasm Grading

KW - Neuroimaging/standards

KW - Perfusion Imaging/standards

KW - Positron-Emission Tomography/standards

KW - Predictive Value of Tests

KW - Time Factors

KW - Treatment Outcome

KW - Tumor Burden

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U2 - 10.1016/S1470-2045(20)30064-4

DO - 10.1016/S1470-2045(20)30064-4

M3 - Review article

C2 - 32502457

AN - SCOPUS:85085650270

SN - 1470-2045

VL - 21

SP - e305-e316

JO - The Lancet Oncology

JF - The Lancet Oncology

IS - 6

ER -

Response assessment in paediatric low-grade glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group

Abstract

Keywords

ASJC Scopus subject areas

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