Abstract
In sporadic ALS (s-ALS), axon terminals contain increased intracellular calcium. Passively transferred sera from patients with s-ALS increase intracellular calcium in spinal motoneuron terminals in vivo and enhance spontaneous transmitter release, a calcium-dependent process. In this study, passive transfer of s-ALS sera increased spontaneous release from spinal but not extraocular motoneuron terminals, suggesting that the resistance to physiologic abnormalities induced by s-ALS sera in mice parallels the resistance of extraocular motoneurons to dysfunction and degeneration in ALS.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 252-255 |
| Number of pages | 4 |
| Journal | Neurology |
| Volume | 54 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 11 2000 |
Keywords
- ALS
- Calcium-binding proteins
- Extraocular muscles
- Neuromuscular junction
- Selective vulnerability
- Transmitter release
ASJC Scopus subject areas
- General Neuroscience
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