Resistance of extraocular motoneuron terminals to effects of amyotrophic lateral sclerosis sera

Dennis R. Mosier, Laszlo Siklós, Stanley H. Appel

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

In sporadic ALS (s-ALS), axon terminals contain increased intracellular calcium. Passively transferred sera from patients with s-ALS increase intracellular calcium in spinal motoneuron terminals in vivo and enhance spontaneous transmitter release, a calcium-dependent process. In this study, passive transfer of s-ALS sera increased spontaneous release from spinal but not extraocular motoneuron terminals, suggesting that the resistance to physiologic abnormalities induced by s-ALS sera in mice parallels the resistance of extraocular motoneurons to dysfunction and degeneration in ALS.

Original languageEnglish (US)
Pages (from-to)252-255
Number of pages4
JournalNeurology
Volume54
Issue number1
DOIs
StatePublished - Jan 11 2000

Keywords

  • ALS
  • Calcium-binding proteins
  • Extraocular muscles
  • Neuromuscular junction
  • Selective vulnerability
  • Transmitter release

ASJC Scopus subject areas

  • Neuroscience(all)

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