Resistance of extraocular motoneuron terminals to effects of amyotrophic lateral sclerosis sera

Dennis R. Mosier; Laszlo Siklós; Stanley H. Appel

doi:10.1212/wnl.54.1.252

Resistance of extraocular motoneuron terminals to effects of amyotrophic lateral sclerosis sera

Dennis R. Mosier, Laszlo Siklós, Stanley H. Appel

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

In sporadic ALS (s-ALS), axon terminals contain increased intracellular calcium. Passively transferred sera from patients with s-ALS increase intracellular calcium in spinal motoneuron terminals in vivo and enhance spontaneous transmitter release, a calcium-dependent process. In this study, passive transfer of s-ALS sera increased spontaneous release from spinal but not extraocular motoneuron terminals, suggesting that the resistance to physiologic abnormalities induced by s-ALS sera in mice parallels the resistance of extraocular motoneurons to dysfunction and degeneration in ALS.

Original language	English (US)
Pages (from-to)	252-255
Number of pages	4
Journal	Neurology
Volume	54
Issue number	1
DOIs	https://doi.org/10.1212/wnl.54.1.252
State	Published - Jan 11 2000

Keywords

ALS
Calcium-binding proteins
Extraocular muscles
Neuromuscular junction
Selective vulnerability
Transmitter release

ASJC Scopus subject areas

Neuroscience(all)

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10.1212/wnl.54.1.252

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title = "Resistance of extraocular motoneuron terminals to effects of amyotrophic lateral sclerosis sera",

abstract = "In sporadic ALS (s-ALS), axon terminals contain increased intracellular calcium. Passively transferred sera from patients with s-ALS increase intracellular calcium in spinal motoneuron terminals in vivo and enhance spontaneous transmitter release, a calcium-dependent process. In this study, passive transfer of s-ALS sera increased spontaneous release from spinal but not extraocular motoneuron terminals, suggesting that the resistance to physiologic abnormalities induced by s-ALS sera in mice parallels the resistance of extraocular motoneurons to dysfunction and degeneration in ALS.",

keywords = "ALS, Calcium-binding proteins, Extraocular muscles, Neuromuscular junction, Selective vulnerability, Transmitter release",

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AU - Mosier, Dennis R.

AU - Siklós, Laszlo

AU - Appel, Stanley H.

PY - 2000/1/11

Y1 - 2000/1/11

N2 - In sporadic ALS (s-ALS), axon terminals contain increased intracellular calcium. Passively transferred sera from patients with s-ALS increase intracellular calcium in spinal motoneuron terminals in vivo and enhance spontaneous transmitter release, a calcium-dependent process. In this study, passive transfer of s-ALS sera increased spontaneous release from spinal but not extraocular motoneuron terminals, suggesting that the resistance to physiologic abnormalities induced by s-ALS sera in mice parallels the resistance of extraocular motoneurons to dysfunction and degeneration in ALS.

AB - In sporadic ALS (s-ALS), axon terminals contain increased intracellular calcium. Passively transferred sera from patients with s-ALS increase intracellular calcium in spinal motoneuron terminals in vivo and enhance spontaneous transmitter release, a calcium-dependent process. In this study, passive transfer of s-ALS sera increased spontaneous release from spinal but not extraocular motoneuron terminals, suggesting that the resistance to physiologic abnormalities induced by s-ALS sera in mice parallels the resistance of extraocular motoneurons to dysfunction and degeneration in ALS.

KW - ALS

KW - Calcium-binding proteins

KW - Extraocular muscles

KW - Neuromuscular junction

KW - Selective vulnerability

KW - Transmitter release

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JO - Neurology

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Resistance of extraocular motoneuron terminals to effects of amyotrophic lateral sclerosis sera

Abstract

Keywords

ASJC Scopus subject areas

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