Resistance in Vancomycin-Resistant Enterococci

William R. Miller; Barbara E. Murray; Louis B. Rice; Cesar A. Arias

doi:10.1016/j.idc.2020.08.004

Resistance in Vancomycin-Resistant Enterococci

William R. Miller, Barbara E. Murray, Louis B. Rice, Cesar A. Arias

Research output: Contribution to journal › Review article › peer-review

85 Scopus citations

Abstract

Serious infections owing to vancomycin-resistant enterococci have historically proven to be difficult clinical cases, requiring combination therapy and management of treatment-related toxicity. Despite the introduction of new antibiotics with activity against vancomycin-resistant enterococci to the therapeutic armamentarium, significant challenges remain. An understanding of the factors driving the emergence of resistance in vancomycin-resistant enterococci, the dynamics of gastrointestinal colonization and microbiota-mediated colonization resistance, and the mechanisms of resistance to the currently available therapeutics will permit clinicians to be better prepared to tackle these challenging hospital-associated pathogens.

Original language	English (US)
Pages (from-to)	751-771
Number of pages	21
Journal	Infectious Disease Clinics of North America
Volume	34
Issue number	4
DOIs	https://doi.org/10.1016/j.idc.2020.08.004
State	Published - Dec 2020

Keywords

Colonization resistance
Mechanisms of resistance
VRE
VRE colonization
Vancomycin resistant enterococcus

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1016/j.idc.2020.08.004

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title = "Resistance in Vancomycin-Resistant Enterococci",

abstract = "Serious infections owing to vancomycin-resistant enterococci have historically proven to be difficult clinical cases, requiring combination therapy and management of treatment-related toxicity. Despite the introduction of new antibiotics with activity against vancomycin-resistant enterococci to the therapeutic armamentarium, significant challenges remain. An understanding of the factors driving the emergence of resistance in vancomycin-resistant enterococci, the dynamics of gastrointestinal colonization and microbiota-mediated colonization resistance, and the mechanisms of resistance to the currently available therapeutics will permit clinicians to be better prepared to tackle these challenging hospital-associated pathogens.",

keywords = "Colonization resistance, Mechanisms of resistance, VRE, VRE colonization, Vancomycin resistant enterococcus",

author = "Miller, {William R.} and Murray, {Barbara E.} and Rice, {Louis B.} and Arias, {Cesar A.}",

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year = "2020",

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doi = "10.1016/j.idc.2020.08.004",

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T1 - Resistance in Vancomycin-Resistant Enterococci

AU - Miller, William R.

AU - Murray, Barbara E.

AU - Rice, Louis B.

AU - Arias, Cesar A.

PY - 2020/12

Y1 - 2020/12

N2 - Serious infections owing to vancomycin-resistant enterococci have historically proven to be difficult clinical cases, requiring combination therapy and management of treatment-related toxicity. Despite the introduction of new antibiotics with activity against vancomycin-resistant enterococci to the therapeutic armamentarium, significant challenges remain. An understanding of the factors driving the emergence of resistance in vancomycin-resistant enterococci, the dynamics of gastrointestinal colonization and microbiota-mediated colonization resistance, and the mechanisms of resistance to the currently available therapeutics will permit clinicians to be better prepared to tackle these challenging hospital-associated pathogens.

AB - Serious infections owing to vancomycin-resistant enterococci have historically proven to be difficult clinical cases, requiring combination therapy and management of treatment-related toxicity. Despite the introduction of new antibiotics with activity against vancomycin-resistant enterococci to the therapeutic armamentarium, significant challenges remain. An understanding of the factors driving the emergence of resistance in vancomycin-resistant enterococci, the dynamics of gastrointestinal colonization and microbiota-mediated colonization resistance, and the mechanisms of resistance to the currently available therapeutics will permit clinicians to be better prepared to tackle these challenging hospital-associated pathogens.

KW - Colonization resistance

KW - Mechanisms of resistance

KW - VRE

KW - VRE colonization

KW - Vancomycin resistant enterococcus

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JO - Infectious Disease Clinics of North America

JF - Infectious Disease Clinics of North America

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ER -

Resistance in Vancomycin-Resistant Enterococci

Abstract

Keywords

ASJC Scopus subject areas

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