Abstract
Serious infections owing to vancomycin-resistant enterococci have historically proven to be difficult clinical cases, requiring combination therapy and management of treatment-related toxicity. Despite the introduction of new antibiotics with activity against vancomycin-resistant enterococci to the therapeutic armamentarium, significant challenges remain. An understanding of the factors driving the emergence of resistance in vancomycin-resistant enterococci, the dynamics of gastrointestinal colonization and microbiota-mediated colonization resistance, and the mechanisms of resistance to the currently available therapeutics will permit clinicians to be better prepared to tackle these challenging hospital-associated pathogens.
Original language | English (US) |
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Pages (from-to) | 751-771 |
Number of pages | 21 |
Journal | Infectious Disease Clinics of North America |
Volume | 34 |
Issue number | 4 |
DOIs | |
State | Published - Dec 2020 |
Keywords
- Colonization resistance
- Mechanisms of resistance
- VRE
- VRE colonization
- Vancomycin resistant enterococcus
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases