Resistance in Vancomycin-Resistant Enterococci

William R. Miller, Barbara E. Murray, Louis B. Rice, Cesar A. Arias

Research output: Contribution to journalReview articlepeer-review

69 Scopus citations


Serious infections owing to vancomycin-resistant enterococci have historically proven to be difficult clinical cases, requiring combination therapy and management of treatment-related toxicity. Despite the introduction of new antibiotics with activity against vancomycin-resistant enterococci to the therapeutic armamentarium, significant challenges remain. An understanding of the factors driving the emergence of resistance in vancomycin-resistant enterococci, the dynamics of gastrointestinal colonization and microbiota-mediated colonization resistance, and the mechanisms of resistance to the currently available therapeutics will permit clinicians to be better prepared to tackle these challenging hospital-associated pathogens.

Original languageEnglish (US)
Pages (from-to)751-771
Number of pages21
JournalInfectious Disease Clinics of North America
Issue number4
StatePublished - Dec 2020


  • Colonization resistance
  • Mechanisms of resistance
  • VRE
  • VRE colonization
  • Vancomycin resistant enterococcus

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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