TY - JOUR
T1 - Research trends in biomedical applications of two-dimensional nanomaterials over the last decade – A bibliometric analysis
AU - Zhu, Shuang
AU - Liu, Yaping
AU - Gu, Zhanjun
AU - Zhao, Yuliang
N1 - Funding Information:
This work was supported by the National Basic Research Program of China (No. 2021YFA1201200 and 2020YFA0710702), the Directional Institutionalized Scientific Research Platform relies on Beijing Synchrotron Radiation Facility of Chinese Academy of Sciences; Strategic Priority Research Program of Chinese Academy of Sciences (No. XDB36000000); the Beijing Natural Science Foundation [2222087].
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/9
Y1 - 2022/9
N2 - Two-dimensional (2D) nanomaterials with versatile properties have been widely applied in the field of biomedicine. Despite various studies having reviewed the development of biomedical 2D nanomaterials, there is a lack of a study that objectively summarizes and analyzes the research trend of this important field. Here, we employ a series of bibliometric methods to identify the development of the 2D nanomaterial-related biomedical field during the past 10 years from a holistic point of view. First, the annual publication/citation growth, country/institute/author distribution, referenced sources, and research hotspots are identified. Thereafter, based on the objectively identified research hotspots, the contributions of 2D nanomaterials to the various biomedical subfields, including those of biosensing, imaging/therapy, antibacterial treatment, and tissue engineering are carefully explored, by considering the intrinsic properties of the nanomaterials. Finally, prospects and challenges have been discussed to shed light on the future development and clinical translation of 2D nanomaterials. This review provides a novel perspective to identify and further promote the development of 2D nanomaterials in biomedical research.
AB - Two-dimensional (2D) nanomaterials with versatile properties have been widely applied in the field of biomedicine. Despite various studies having reviewed the development of biomedical 2D nanomaterials, there is a lack of a study that objectively summarizes and analyzes the research trend of this important field. Here, we employ a series of bibliometric methods to identify the development of the 2D nanomaterial-related biomedical field during the past 10 years from a holistic point of view. First, the annual publication/citation growth, country/institute/author distribution, referenced sources, and research hotspots are identified. Thereafter, based on the objectively identified research hotspots, the contributions of 2D nanomaterials to the various biomedical subfields, including those of biosensing, imaging/therapy, antibacterial treatment, and tissue engineering are carefully explored, by considering the intrinsic properties of the nanomaterials. Finally, prospects and challenges have been discussed to shed light on the future development and clinical translation of 2D nanomaterials. This review provides a novel perspective to identify and further promote the development of 2D nanomaterials in biomedical research.
KW - 2D nanomaterials
KW - Bibliometric analysis
KW - Biomedical applications
KW - Nanosheets
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U2 - 10.1016/j.addr.2022.114420
DO - 10.1016/j.addr.2022.114420
M3 - Review article
C2 - 35835354
AN - SCOPUS:85134707709
SN - 0169-409X
VL - 188
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
M1 - 114420
ER -