Research progress of ischemia-free liver transplantation

Ming Xi Zhang; Qiang Zhao; Xiao Shun He

doi:10.1016/j.hbpd.2024.10.002

Research progress of ischemia-free liver transplantation

Ming Xi Zhang, Qiang Zhao, Xiao Shun He

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Ischemia-reperfusion injury (IRI) is an inherent issue in organ transplantation. Because of the allograft shortage, more and more extended criteria donor (ECD) organs are used, unfortunately these grafts are more susceptible to IRI. Although machine perfusion technology has brought hope to alleviate IRI, this technology is still unable to eradicate IRI-related organ damage. Ischemia-free liver transplantation (IFLT) can completely avoid IRI, thereby improve graft function and recipient outcome, and allow to expand organ pool. This review summarized the latest progresses in IFLT, and speculated the future development of this concept.

Original language	English (US)
Pages (from-to)	18-22
Number of pages	5
Journal	Hepatobiliary and Pancreatic Diseases International
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/j.hbpd.2024.10.002
State	Published - Feb 2025

Keywords

Ischemia-free liver transplantation
Ischemia-reperfusion injury
Normothermic machine perfusion

ASJC Scopus subject areas

Hepatology
Gastroenterology

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10.1016/j.hbpd.2024.10.002

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title = "Research progress of ischemia-free liver transplantation",

abstract = "Ischemia-reperfusion injury (IRI) is an inherent issue in organ transplantation. Because of the allograft shortage, more and more extended criteria donor (ECD) organs are used, unfortunately these grafts are more susceptible to IRI. Although machine perfusion technology has brought hope to alleviate IRI, this technology is still unable to eradicate IRI-related organ damage. Ischemia-free liver transplantation (IFLT) can completely avoid IRI, thereby improve graft function and recipient outcome, and allow to expand organ pool. This review summarized the latest progresses in IFLT, and speculated the future development of this concept.",

keywords = "Ischemia-free liver transplantation, Ischemia-reperfusion injury, Normothermic machine perfusion",

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AU - Zhao, Qiang

AU - He, Xiao Shun

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AB - Ischemia-reperfusion injury (IRI) is an inherent issue in organ transplantation. Because of the allograft shortage, more and more extended criteria donor (ECD) organs are used, unfortunately these grafts are more susceptible to IRI. Although machine perfusion technology has brought hope to alleviate IRI, this technology is still unable to eradicate IRI-related organ damage. Ischemia-free liver transplantation (IFLT) can completely avoid IRI, thereby improve graft function and recipient outcome, and allow to expand organ pool. This review summarized the latest progresses in IFLT, and speculated the future development of this concept.

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KW - Normothermic machine perfusion

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Research progress of ischemia-free liver transplantation

Abstract

Keywords

ASJC Scopus subject areas

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