TY - JOUR
T1 - Research Opportunities in the Treatment of Mitral Valve Prolapse
T2 - JACC Expert Panel
AU - Delling, Francesca N.
AU - Noseworthy, Peter A.
AU - Adams, David H.
AU - Basso, Cristina
AU - Borger, Michael
AU - Bouatia-Naji, Nabila
AU - Elmariah, Sammy
AU - Evans, Frank
AU - Gerstenfeld, Edward
AU - Hung, Judy
AU - Le Tourneau, Thierry
AU - Lewis, John
AU - Miller, Marc A.
AU - Norris, Russell A.
AU - Padala, Muralidhar
AU - Perazzolo-Marra, Martina
AU - Shah, Dipan J.
AU - Weinsaft, Jonathan W.
AU - Enriquez-Sarano, Maurice
AU - Levine, Robert A.
N1 - Publisher Copyright:
© 2022 The Authors
PY - 2022/12/13
Y1 - 2022/12/13
N2 - In light of the adverse prognosis related to severe mitral regurgitation, heart failure, or sudden cardiac death in a subset of patients with mitral valve prolapse (MVP), identifying those at higher risk is key. For the first time in decades, researchers have the means to rapidly advance discovery in the field of MVP thanks to state-of-the-art imaging techniques, novel omics methodologies, and the potential for large-scale collaborations using web-based platforms. The National Heart, Lung, and Blood Institute recently initiated a webinar-based workshop to identify contemporary research opportunities in the treatment of MVP. This report summarizes 3 specific areas in the treatment of MVP that were the focus of the workshop: 1) improving management of degenerative mitral regurgitation and associated left ventricular systolic dysfunction; 2) preventing sudden cardiac death in MVP; and 3) understanding the mechanisms and progression of MVP through genetic studies and small and large animal models, with the potential of developing medical therapies.
AB - In light of the adverse prognosis related to severe mitral regurgitation, heart failure, or sudden cardiac death in a subset of patients with mitral valve prolapse (MVP), identifying those at higher risk is key. For the first time in decades, researchers have the means to rapidly advance discovery in the field of MVP thanks to state-of-the-art imaging techniques, novel omics methodologies, and the potential for large-scale collaborations using web-based platforms. The National Heart, Lung, and Blood Institute recently initiated a webinar-based workshop to identify contemporary research opportunities in the treatment of MVP. This report summarizes 3 specific areas in the treatment of MVP that were the focus of the workshop: 1) improving management of degenerative mitral regurgitation and associated left ventricular systolic dysfunction; 2) preventing sudden cardiac death in MVP; and 3) understanding the mechanisms and progression of MVP through genetic studies and small and large animal models, with the potential of developing medical therapies.
KW - cardiac magnetic resonance imaging
KW - echocardiography
KW - mitral regurgitation
KW - mitral valve prolapse
KW - sudden cardiac death
UR - http://www.scopus.com/inward/record.url?scp=85142841227&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85142841227&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2022.09.044
DO - 10.1016/j.jacc.2022.09.044
M3 - Review article
C2 - 36480975
AN - SCOPUS:85142841227
SN - 0735-1097
VL - 80
SP - 2331
EP - 2347
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 24
ER -