Requirement for IL-13 independently of IL-4 in experimental asthma

Gabriele Grünig, Martha Warnock, Adil E. Wakil, Rajeev Venkayya, Frank Brombacher, Donna M. Rennick, Dean Sheppard, Markus Mohrs, Debra D. Donaldson, Richard M. Locksley, David B. Corry

    Research output: Contribution to journalArticlepeer-review

    1777 Scopus citations

    Abstract

    The pathogenesis of asthma reflects, in part, the activity of T cell cytokines. Murine models support participation of interleukin-4 (IL-4) and the IL-4 receptor in asthma. Selective neutralization of IL-13, a cytokine related to IL-4 that also binds to the α chain of the IL-4 receptor, ameliorated the asthma phenotype, including airways hyperresponsiveness, eosinophil recruitment, and mucus overproduction. Administration of either IL-13 or IL-4 conferred an asthma-like phenotype to nonimmunized T cell- deficient mice by an IL-4 receptor α chain-dependent pathway. This pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL-4 receptor.

    Original languageEnglish (US)
    Pages (from-to)2261-2263
    Number of pages3
    JournalScience
    Volume282
    Issue number5397
    DOIs
    StatePublished - Dec 18 1998

    ASJC Scopus subject areas

    • General

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