Abstract
A case of renal-cell carcinoma (RCC) exhibiting prominent intranuclear inclusions in a metastasis to the thyroid is presented. RCC had been treated in this patient by right nephrectomy 7 yr earlier and by left partial nephrectomy 5 yr earlier; the patient had also received radiation to the neck 4 yr earlier for carcinoma in situ of the left true vocal cord. Aspiration performed on a rapidly enlarging mass in the left lobe of the thyroid revealed both clusters of tumor cells and single tumor cells with prominent intranuclear inclusions. Definitive distinction between a primary and metastatic neoplasm was difficult on the aspiration specimen. Subsequent thyroidectomy confirmed the diagnosis of metastatic renal-cell carcinoma with intranuclear inclusions by histologic, immunohistochemical, and ultrastructural analysis. The differential diagnosis by aspiration cytology of thyroid neoplasms that contain intranuclear inclusions is discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 125-129 |
| Number of pages | 5 |
| Journal | Diagnostic Cytopathology |
| Volume | 4 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 1988 |
Keywords
- Intranuclear inclusions
- Metastatic renal‐cell carcinoma
- Papillary thyroid carcinoma
- Thyroid
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology
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