Renal‐cell carcinoma with intranuclear inclusions metastatic to thyroid: A diagnostic problem in aspiration cytology

Andrey Y. Gritsman, Steven M. Popok, Jae Ro, Roupen H. Dekmezian, Randal S. Weber

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

A case of renal-cell carcinoma (RCC) exhibiting prominent intranuclear inclusions in a metastasis to the thyroid is presented. RCC had been treated in this patient by right nephrectomy 7 yr earlier and by left partial nephrectomy 5 yr earlier; the patient had also received radiation to the neck 4 yr earlier for carcinoma in situ of the left true vocal cord. Aspiration performed on a rapidly enlarging mass in the left lobe of the thyroid revealed both clusters of tumor cells and single tumor cells with prominent intranuclear inclusions. Definitive distinction between a primary and metastatic neoplasm was difficult on the aspiration specimen. Subsequent thyroidectomy confirmed the diagnosis of metastatic renal-cell carcinoma with intranuclear inclusions by histologic, immunohistochemical, and ultrastructural analysis. The differential diagnosis by aspiration cytology of thyroid neoplasms that contain intranuclear inclusions is discussed.

Original languageEnglish (US)
Pages (from-to)125-129
Number of pages5
JournalDiagnostic Cytopathology
Volume4
Issue number2
DOIs
StatePublished - Jan 1 1988

Keywords

  • Intranuclear inclusions
  • Metastatic renal‐cell carcinoma
  • Papillary thyroid carcinoma
  • Thyroid

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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