TY - JOUR
T1 - Renal‐cell carcinoma with intranuclear inclusions metastatic to thyroid
T2 - A diagnostic problem in aspiration cytology
AU - Gritsman, Andrey Y.
AU - Popok, Steven M.
AU - Ro, Jae Y.
AU - Dekmezian, Roupen H.
AU - Weber, Randal S.
PY - 1988/3
Y1 - 1988/3
N2 - A case of renal-cell carcinoma (RCC) exhibiting prominent intranuclear inclusions in a metastasis to the thyroid is presented. RCC had been treated in this patient by right nephrectomy 7 yr earlier and by left partial nephrectomy 5 yr earlier; the patient had also received radiation to the neck 4 yr earlier for carcinoma in situ of the left true vocal cord. Aspiration performed on a rapidly enlarging mass in the left lobe of the thyroid revealed both clusters of tumor cells and single tumor cells with prominent intranuclear inclusions. Definitive distinction between a primary and metastatic neoplasm was difficult on the aspiration specimen. Subsequent thyroidectomy confirmed the diagnosis of metastatic renal-cell carcinoma with intranuclear inclusions by histologic, immunohistochemical, and ultrastructural analysis. The differential diagnosis by aspiration cytology of thyroid neoplasms that contain intranuclear inclusions is discussed.
AB - A case of renal-cell carcinoma (RCC) exhibiting prominent intranuclear inclusions in a metastasis to the thyroid is presented. RCC had been treated in this patient by right nephrectomy 7 yr earlier and by left partial nephrectomy 5 yr earlier; the patient had also received radiation to the neck 4 yr earlier for carcinoma in situ of the left true vocal cord. Aspiration performed on a rapidly enlarging mass in the left lobe of the thyroid revealed both clusters of tumor cells and single tumor cells with prominent intranuclear inclusions. Definitive distinction between a primary and metastatic neoplasm was difficult on the aspiration specimen. Subsequent thyroidectomy confirmed the diagnosis of metastatic renal-cell carcinoma with intranuclear inclusions by histologic, immunohistochemical, and ultrastructural analysis. The differential diagnosis by aspiration cytology of thyroid neoplasms that contain intranuclear inclusions is discussed.
KW - Intranuclear inclusions
KW - Metastatic renal‐cell carcinoma
KW - Papillary thyroid carcinoma
KW - Thyroid
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U2 - 10.1002/dc.2840040209
DO - 10.1002/dc.2840040209
M3 - Article
C2 - 3243157
AN - SCOPUS:0024234382
SN - 8755-1039
VL - 4
SP - 125
EP - 129
JO - Diagnostic Cytopathology
JF - Diagnostic Cytopathology
IS - 2
ER -