Abstract

Tumors of many histological types can arise from the kidney. However, only a few account for the majority. Renal cell carcinoma (RCC) and nephroblastoma account for more than 80% of the renal tumors in adults and children, respectively. The Light microscopic morphology has been the foundation for tumor classification. More recently, the protein profiles, chromosomal changes, and pathogenic gene mutation associated with, or responsible for, several histological tumor types were elucidated. These novel findings help refine the tumor classification, elucidate the molecular mechanism of tumor formation, and define molecular targets for tumor-specific therapy. This article provides an overview of renal neoplasms and focuses on RCC, benign renal neoplasms, and nephroblastoma, with an emphasis on pathobiological and molecular attributes.

Original languageEnglish (US)
Title of host publicationPathobiology of Human Disease
Subtitle of host publicationA Dynamic Encyclopedia of Disease Mechanisms
PublisherElsevier Inc.
Pages2869-2899
Number of pages31
ISBN (Electronic)9780123864567
ISBN (Print)9780123864574
DOIs
StatePublished - Jan 1 2014

Keywords

  • Benign renal tumors
  • Chromosomal abnormaLities
  • Epidemiology
  • Etiopathogenesis
  • FamiLial renal cancers
  • Fluorescent in situ hybridization
  • Immunohistochemistry
  • Molecular changes
  • Nephroblastoma
  • Pathobiology
  • Pathogenesis
  • Pediatric renal tumors
  • Renal cell carcinoma
  • Renal epitheLial tumors
  • Risk factors

ASJC Scopus subject areas

  • Medicine(all)

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