Renal Toxicity

Maen Abdelrahim; Ala Abudayyeh

doi:10.1007/978-3-030-41008-7_16

Renal Toxicity

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

With the increasing use of immunotherapy, there has been an associated increased survival in many cancers but has also resulted in unregulated organ-specific toxicities. In this chapter, we discuss the renal toxicities associated with a checkpoint inhibitor (CPI) from the typical acute tubulointersitial nephritis to glomerulonephritis, their proposed mechanisms, and treatments. We also discuss the use of CPI and reactivation of preexisting auto-immune diseases and focus on renal cell cancer in setting of Chronic kidney disease (CKD). Transplant rejection in the setting of CPI use is yet to be further studied, and available data is presented in this chapter.

Original language	English (US)
Title of host publication	Advances in Experimental Medicine and Biology
Publisher	Springer
Pages	287-293
Number of pages	7
Volume	1244
DOIs	https://doi.org/10.1007/978-3-030-41008-7_16
State	E-pub ahead of print - Apr 17 2020

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	1244
ISSN (Print)	0065-2598
ISSN (Electronic)	2214-8019

Keywords

Acute interstitial nephritis
Autoimmune disease induction
Immune-related adverse events
Organ transplant rejection
Renal cell cancer

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/978-3-030-41008-7_16

Cite this

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AU - Abdelrahim, Maen

AU - Abudayyeh, Ala

PY - 2020/4/17

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AB - With the increasing use of immunotherapy, there has been an associated increased survival in many cancers but has also resulted in unregulated organ-specific toxicities. In this chapter, we discuss the renal toxicities associated with a checkpoint inhibitor (CPI) from the typical acute tubulointersitial nephritis to glomerulonephritis, their proposed mechanisms, and treatments. We also discuss the use of CPI and reactivation of preexisting auto-immune diseases and focus on renal cell cancer in setting of Chronic kidney disease (CKD). Transplant rejection in the setting of CPI use is yet to be further studied, and available data is presented in this chapter.

KW - Acute interstitial nephritis

KW - Autoimmune disease induction

KW - Immune-related adverse events

KW - Organ transplant rejection

KW - Renal cell cancer

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Renal Toxicity

Abstract

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Keywords

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