Renal excretion of calcium and magnesium during acetazolamide or parathyroid hormone administration in dogs with distal blockade

R. A. Peraino, D. Rouse, B. J. Stinebaugh, Wadi N. Suki

Research output: Contribution to journalArticle

Abstract

Renal absorption of calcium and magnesium occurs in the proximal tubule, and at unknown site(s) beyond this segment. In the presence of blockade of Henle's loop by ethacrynic acid, the excretion of calcium, magnesium and sodium in response to acetazolamide as compared to that with parathyroid hormone (PTH) was examined. Addition of acetazolamide to ethacrynic acid increased calcium and sodium excretion, but did not change magnesium excretion. In contrast, PTH added to ethacrynic acid did not change the excretion of any of the ions under investigation. Analysis of calcium and magnesium excretion as a function of sodium excretion, however, suggests that ethacrynic acid inhibited the effect of PTH to augment calcium absorption, but did not alter magnesium absorption, implying that the nephron site of PTH action to augment calcium absorption is the ascending limb of Henle's loop and that to augment magnesium absorption resides beyond Henle's loop.

Original languageEnglish (US)
Pages (from-to)19-27
Number of pages9
JournalRenal Physiology
Volume1
Issue number1
StatePublished - Jan 1 1978

ASJC Scopus subject areas

  • Physiology
  • Nephrology

Fingerprint Dive into the research topics of 'Renal excretion of calcium and magnesium during acetazolamide or parathyroid hormone administration in dogs with distal blockade'. Together they form a unique fingerprint.

Cite this