TY - JOUR
T1 - Renal cystic neoplasms and renal neoplasms associated with cystic renal diseases
T2 - Pathogenetic and molecular links
AU - Truong, Luan
AU - Choi, Yeong Jin
AU - Shen, Steven
AU - Ayala, Gustavo
AU - Amato, Robert
AU - Krishnan, Bhuvaneswari
PY - 2003/5/1
Y1 - 2003/5/1
N2 - Cystic renal neoplasms represent an isolated cystic mass not accompanied by cystic change of the renal parenchyma. Although cystic change may be seen in any type of renal neoplasm, a few (i.e., cystic renal cell carcinoma, cystic nephroma, cystic partially differentiated nephroblastoma, mixed epithelial and stromal tumor) are characterized by constant cystic change that may involve the entire tumor. Cystic kidney disease is characterized by cystic change, which usually involves the kidneys in a bilateral and diffuse pattern, does not create a discreet mass, and is due to hereditary or developmental conditions. Some of the cystic kidney diseases are not known to give rise to renal neoplasm; others such as autosomal polycystic kidney disease or multicystic dysplastic kidney may fortuitously coexist with renal neoplasms. Three conditions (acquired cystic kidney disease, tuberous sclerosis, and von Hippel-Lindau disease) are associated with renal neoplasms with such a high frequency that they are considered preneoplastic. This article reviews the differential diagnoses among cystic neoplasms. It also focuses on the underlying genetic and molecular mechanisms for the relationship between cystic renal diseases and renal neoplasms.
AB - Cystic renal neoplasms represent an isolated cystic mass not accompanied by cystic change of the renal parenchyma. Although cystic change may be seen in any type of renal neoplasm, a few (i.e., cystic renal cell carcinoma, cystic nephroma, cystic partially differentiated nephroblastoma, mixed epithelial and stromal tumor) are characterized by constant cystic change that may involve the entire tumor. Cystic kidney disease is characterized by cystic change, which usually involves the kidneys in a bilateral and diffuse pattern, does not create a discreet mass, and is due to hereditary or developmental conditions. Some of the cystic kidney diseases are not known to give rise to renal neoplasm; others such as autosomal polycystic kidney disease or multicystic dysplastic kidney may fortuitously coexist with renal neoplasms. Three conditions (acquired cystic kidney disease, tuberous sclerosis, and von Hippel-Lindau disease) are associated with renal neoplasms with such a high frequency that they are considered preneoplastic. This article reviews the differential diagnoses among cystic neoplasms. It also focuses on the underlying genetic and molecular mechanisms for the relationship between cystic renal diseases and renal neoplasms.
KW - Cystic kidney diseases
KW - Cystic neoplasms
KW - Kidney
KW - Renal cell carcinoma
KW - Review
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U2 - 10.1097/00125480-200305000-00003
DO - 10.1097/00125480-200305000-00003
M3 - Review article
C2 - 12717117
AN - SCOPUS:0642373778
VL - 10
SP - 135
EP - 159
JO - Advances in Anatomic Pathology
JF - Advances in Anatomic Pathology
SN - 1072-4109
IS - 3
ER -