Renal cystic neoplasms and renal neoplasms associated with cystic renal diseases: Pathogenetic and molecular links

Luan Truong, Yeong Jin Choi, Steven Shen, Gustavo Ayala, Robert Amato, Bhuvaneswari Krishnan

Research output: Contribution to journalReview article

84 Scopus citations

Abstract

Cystic renal neoplasms represent an isolated cystic mass not accompanied by cystic change of the renal parenchyma. Although cystic change may be seen in any type of renal neoplasm, a few (i.e., cystic renal cell carcinoma, cystic nephroma, cystic partially differentiated nephroblastoma, mixed epithelial and stromal tumor) are characterized by constant cystic change that may involve the entire tumor. Cystic kidney disease is characterized by cystic change, which usually involves the kidneys in a bilateral and diffuse pattern, does not create a discreet mass, and is due to hereditary or developmental conditions. Some of the cystic kidney diseases are not known to give rise to renal neoplasm; others such as autosomal polycystic kidney disease or multicystic dysplastic kidney may fortuitously coexist with renal neoplasms. Three conditions (acquired cystic kidney disease, tuberous sclerosis, and von Hippel-Lindau disease) are associated with renal neoplasms with such a high frequency that they are considered preneoplastic. This article reviews the differential diagnoses among cystic neoplasms. It also focuses on the underlying genetic and molecular mechanisms for the relationship between cystic renal diseases and renal neoplasms.

Original languageEnglish (US)
Pages (from-to)135-159
Number of pages25
JournalAdvances in Anatomic Pathology
Volume10
Issue number3
DOIs
StatePublished - May 1 2003

Keywords

  • Cystic kidney diseases
  • Cystic neoplasms
  • Kidney
  • Renal cell carcinoma
  • Review

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Anatomy

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