Renal concentrating mechanism: Possible role for sodium-potassium activated adenosine triphosphatase

M. Martinez-Maldonado, J. C. Allen, G. Eknoyan, Wadi N. Suki, A. Schwartz

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Sodium-potassium activated adenosine triphosphatase activity was found to be almost twice as high in renal medulla as in cortex. Infusion of digoxin, a specific inhibitor of the enzyme, into one renal artery of the dog resulted in unilateral natriuresis, impaired concentrating capacity, and reduction of the enzyme activity in both cortex and medulla. It is suggested that the sodium-potassium adenosine triphosphatase plays an important role in urine concentration mechanisms.

Original languageEnglish (US)
Pages (from-to)807-808
Number of pages2
JournalScience
Volume165
Issue number3895
DOIs
StatePublished - Jan 1 1969

ASJC Scopus subject areas

  • General

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