TY - JOUR
T1 - Renal concentrating mechanism
T2 - Possible role for sodium-potassium activated adenosine triphosphatase
AU - Martinez-Maldonado, M.
AU - Allen, J. C.
AU - Eknoyan, G.
AU - Suki, Wadi N.
AU - Schwartz, A.
PY - 1969/1/1
Y1 - 1969/1/1
N2 - Sodium-potassium activated adenosine triphosphatase activity was found to be almost twice as high in renal medulla as in cortex. Infusion of digoxin, a specific inhibitor of the enzyme, into one renal artery of the dog resulted in unilateral natriuresis, impaired concentrating capacity, and reduction of the enzyme activity in both cortex and medulla. It is suggested that the sodium-potassium adenosine triphosphatase plays an important role in urine concentration mechanisms.
AB - Sodium-potassium activated adenosine triphosphatase activity was found to be almost twice as high in renal medulla as in cortex. Infusion of digoxin, a specific inhibitor of the enzyme, into one renal artery of the dog resulted in unilateral natriuresis, impaired concentrating capacity, and reduction of the enzyme activity in both cortex and medulla. It is suggested that the sodium-potassium adenosine triphosphatase plays an important role in urine concentration mechanisms.
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U2 - 10.1126/science.165.3895.807
DO - 10.1126/science.165.3895.807
M3 - Article
C2 - 4240334
AN - SCOPUS:0014687761
SN - 0036-8075
VL - 165
SP - 807
EP - 808
JO - Science
JF - Science
IS - 3895
ER -