Removal of acetylaminofluorene from the DNA of control and repair-deficient human fibroblasts

David E. Amacher; Michael W. Lieberman

doi:10.1016/0006-291X(77)91406-1

Removal of acetylaminofluorene from the DNA of control and repair-deficient human fibroblasts

David E. Amacher, Michael W. Lieberman

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Removal of covalently-bound acetylaminofluorene (AAF) from DNA was studied in confluent (non-dividing) control and repair-deficient human fibroblasts. Control fibroblasts and fibroblasts from individuals with Fanconi's anemia and ataxia telangiectasia removed about 50% of the bound AAF in 48 hours. Fibroblasts from individuals with xeroderma pigmentosum (XP) (complementation groups A and C) removed little AAF while XP variants appeared to remove AAF as well as, or almost as well as, control cells.

Original language	English (US)
Pages (from-to)	285-290
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	74
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(77)91406-1
State	Published - Jan 10 1977

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0006-291X(77)91406-1

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abstract = "Removal of covalently-bound acetylaminofluorene (AAF) from DNA was studied in confluent (non-dividing) control and repair-deficient human fibroblasts. Control fibroblasts and fibroblasts from individuals with Fanconi's anemia and ataxia telangiectasia removed about 50\% of the bound AAF in 48 hours. Fibroblasts from individuals with xeroderma pigmentosum (XP) (complementation groups A and C) removed little AAF while XP variants appeared to remove AAF as well as, or almost as well as, control cells.",

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AU - Lieberman, Michael W.

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N2 - Removal of covalently-bound acetylaminofluorene (AAF) from DNA was studied in confluent (non-dividing) control and repair-deficient human fibroblasts. Control fibroblasts and fibroblasts from individuals with Fanconi's anemia and ataxia telangiectasia removed about 50% of the bound AAF in 48 hours. Fibroblasts from individuals with xeroderma pigmentosum (XP) (complementation groups A and C) removed little AAF while XP variants appeared to remove AAF as well as, or almost as well as, control cells.

AB - Removal of covalently-bound acetylaminofluorene (AAF) from DNA was studied in confluent (non-dividing) control and repair-deficient human fibroblasts. Control fibroblasts and fibroblasts from individuals with Fanconi's anemia and ataxia telangiectasia removed about 50% of the bound AAF in 48 hours. Fibroblasts from individuals with xeroderma pigmentosum (XP) (complementation groups A and C) removed little AAF while XP variants appeared to remove AAF as well as, or almost as well as, control cells.

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Removal of acetylaminofluorene from the DNA of control and repair-deficient human fibroblasts

Abstract

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